• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Effect of a glucosyltransferase inhibitor on glucan synthesis and cellular adherence of Streptococcus mutans.
【24h】

Effect of a glucosyltransferase inhibitor on glucan synthesis and cellular adherence of Streptococcus mutans.

机译：葡糖基转移酶抑制剂对变形链球菌葡聚糖合成和细胞粘附的影响。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The effects of mutastein, a glucosyltransferase inhibitor derived from an Aspergillus terreus strain, on the glucan synthesis by glucosyltransferases of Streptococcus mutans and sucrose-dependent adherence of S. mutans cells were examined in vitro. The synthesis of insoluble glucan by crude glucosyltransferase of S. mutans strain B13 was markedly inhibited by mutastein at a final concentration of 10 micrograms of protein/ml. The synthesis of insoluble glucan adherent to glass surfaces was almost completely inhibited by mutastein at this concentration. In addition, mutastein inhibited the sucrose-dependent adherence to glass surfaces of resting and growing cells of various S. mutans strains. These results suggest that mutastein could be useful for controlling dental plaque and dental caries in vivo.
机译：在体外检查了突变体，一种源自土曲霉菌株的葡糖基转移酶抑制剂，对变形链球菌葡糖基转移酶的葡聚糖合成和蔗糖依赖性粘附的影响。变异链球菌菌株B13的粗葡糖基转移酶合成的不溶性葡聚糖在最终浓度为10微克蛋白/ ml时被mutastein显着抑制。在此浓度下，诱变剂几乎完全抑制粘附在玻璃表面的不溶葡聚糖的合成。此外，mutastein抑制了蔗糖依赖性粘附在各种变形链球菌菌株的静止和生长细胞的玻璃表面上。这些结果表明，诱变剂可用于体内控制牙菌斑和龋齿。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号