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首页> 外文期刊>Infection and immunity >Cryptococcus neoformans: size range of infectious particles from aerosolized soil.
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Cryptococcus neoformans: size range of infectious particles from aerosolized soil.

机译：新型隐球菌：来自雾化土壤的感染性颗粒的大小范围。

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Although cryptococcosis is characterized as a chronic central nervous system disease, it is generally accepted that the lungs are the primary portal of entry for the etiological agent. Despite this, there is a distinct lack of evidence that viable airborne particles of Cryptococcus neoformans are small enough to reach the alveoli. Two encapsulated strains and one nonencapsulated strain of C. neoformans were inoculated into 250-g quantities of sterile soil. Throughout the 0 to 12 weeks of incubation, this soil was aerosolized in a sealed chamber with a Waring blender. Samples of the resultant dust cloud were taken with an Anderson air sampler from which the numbers and sizes of viable airborne particles were determined. Of the viable organisms aspirated into the air sampler, 15% were 0.65 to 2 micron in diameter. As incubation time in soil increased, the size of the particles decreased, and increased numbers of C. neoformans cells 0.65 to 2 micron in diameter were isolated. The presence of viable cells less than 2 micron in soil aerosols indicated that, under certain conditions in nature, C. neoformans cells exist in sizes that are capable of deep lung deposition.
机译：尽管隐球菌病的特征是慢性中枢神经系统疾病，但人们普遍认为肺是病原体进入的主要入口。尽管如此，仍明显缺乏证据表明新隐球菌的空气传播颗粒小到足以到达肺泡。将两种封装的菌株和一种未封装的新孢梭菌菌株接种到250 g量的无菌土壤中。在整个0到12周的培养过程中，使用Waring搅拌器在密封的室内将土壤雾化。用安德森空气采样器采集所得尘埃云的样品，从中确定可行的空气传播颗粒的数量和大小。吸入空气采样器的活生物体中，有15％的直径为0.65至2微米。随着在土壤中孵育时间的增加，颗粒的大小减小，并且分离到直径为0.65至2微米的新孢梭菌细胞数量增加。土壤气溶胶中小于2微米的活细胞的存在表明，在自然界中的某些条件下，新形成梭状芽胞杆菌细胞的大小能够使肺深层沉积。

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