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Variation Between Strains of Hamsters in the Lethality of Pichinde Virus Infections

机译：棘突病毒感染致命性中仓鼠菌株之间的变异

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Infection by Pichinde virus, a member of the arenavirus group, was studied in Golden Syrian hamsters (Mesocricetus auratus) with regard to possible mechanisms of resistance to virus infection in adult hamsters. Two hamster strains were found to differ in their susceptibility to lethal Pichinde virus infection. LVG/Lak randomly bred hamsters were found to be 100% susceptible to low doses of Pichinde virus during the first 6 days of life, but after 8 days of life, mortality was uncommon. Peak virus titers in the serum of animals infected at 3 days of life were 4 logs greater than in animals infected at 12 days. MHA/Lak inbred hamsters, in contrast, were found to be susceptible to lethal virus infection both as newborns and as adults. Peak virus titers of greater than 108 plaque-forming units/ml were observed in serum 8 days after infection of adult MHA hamsters as compared with less than 103 plaque-forming units/ml in the serum of adult LVG hamsters. Cultured primary kidney cells and peritoneal macrophages from either hamster strain supported Pichinde virus replication equally well in vitro. Antibodies to the complement-fixing antigens and to antigens at the surface of virus-infected cells were produced by both strains of hamsters. Cyclophosphamide immunosuppression rendered adult LVG animals susceptible to lethal infections, and virus grew to high titers in the treated animals. These findings suggest that immunological factors that appear early in life in LVG hamsters and are deficient in MHA hamsters limit Pichinde virus infection. Unlike previously reported arenavirus diseases, the observations suggest that death is produced by a direct viral effect and not through immunopathological mechanisms.
机译：在金色叙利亚仓鼠（ cricritus auratus ）中研究了沙粒病毒群成员Pichinde病毒的感染，研究了成年仓鼠对病毒感染的抗性机制。发现两种仓鼠菌株在致死性Pichinde病毒感染方面的敏感性不同。发现LVG / Lak随机繁殖的仓鼠在生命的前6天对低剂量的Pichinde病毒具有100％的敏感性，但在生命8天后，死亡率并不常见。在生命的3天时感染的动物血清中的病毒滴度峰值比在12天时被感染的动物高4个对数。相比之下，MHA / Lak近交仓鼠无论是新生儿还是成人都容易受到致命病毒感染。在成年MHA仓鼠感染后第8天，血清中病毒滴度峰值峰值大于10 8 ，而少于10 3 成人LVG仓鼠血清中的单位/毫升。来自任一仓鼠菌株的培养的原代肾细胞和腹膜巨噬细胞在体外均同样良好地支持Pichinde病毒复制。由两种仓鼠菌株产生补体固定抗原和病毒感染细胞表面抗原的抗体。环磷酰胺免疫抑制使成年LVG动物易受致死性感染，并且病毒在治疗的动物中生长至高滴度。这些发现表明，在LVG仓鼠中较早出现并缺乏MHA仓鼠的免疫因素限制了Pichinde病毒的感染。与以前报道的鼻病毒不同，这些观察结果表明死亡是由直接的病毒作用而不是通过免疫病理机制引起的。

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