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首页> 外文期刊>Infection and immunity >Resistance and susceptibility of mice to bacterial infection: course of listeriosis in resistant or susceptible mice.
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Resistance and susceptibility of mice to bacterial infection: course of listeriosis in resistant or susceptible mice.

机译：小鼠对细菌感染的耐药性和易感性：耐药或易感小鼠的李斯特菌病病程。

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Resistance and susceptibility to Listeria monocytogenes in mice was found to be related to (i) the innate ability of the nonimmune macrophages to kill or inhibit the growth of the organism during the first 24 to 48 h after infection, and (ii) the time of onset of acquired cell-mediated resistance. Resistant C57Bl/6 mice were 10 times more efficient than susceptible BALB/c mice at suppressing the early growth of Listeria in the liver. Furthermore, the onset of acquired immunity occurred 24 to 48 h earlier in C57Bl/6 than in BALB/c mice. Acquired immunity was measured by (i) fall in bacterial numbers in spleen and livers of infected mice (ii) adoptive transfer of immunity to normal mice by using spleen cells from infected mice, (iii) delayed-type hypersensitivity skin testing, and (iv) uptake of tritiated thymidine by lymphocytes in the spleen.
机译：已发现小鼠对单核细胞增生性李斯特菌的耐药性和易感性与（i）非免疫巨噬细胞在感染后的最初24至48小时内杀死或抑制生物体生长的先天能力有关，以及（ii）获得性细胞介导的耐药性的发作。抗C57Bl / 6小鼠在抑制肝中李斯特菌的早期生长方面比易感BALB / c小鼠高10倍。此外，与BALB / c小鼠相比，C57Bl / 6中获得性免疫的发作提前24至48小时。通过（i）受感染小鼠的脾脏和肝脏中细菌数量的下降来测量获得的免疫力（ii）通过使用来自受感染小鼠的脾细胞将免疫力过继转移至正常小鼠，（iii）迟发型超敏反应皮肤测试和（iv ）脾脏中的淋巴细胞对tri化胸腺嘧啶核苷的摄取

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