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首页> 外文期刊>Infection and immunity >Immunosuppressive activity of BCG: effects of adjuvant disease, lymphocyte subpopulations, and homing of thoracic duct cells in rats.
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Immunosuppressive activity of BCG: effects of adjuvant disease, lymphocyte subpopulations, and homing of thoracic duct cells in rats.

机译：卡介苗的免疫抑制活性：佐剂疾病，淋巴细胞亚群和大鼠胸导管细胞归巢的影响。

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Administration of BCG by various dosage schedules suppressed adjuvant disease in rats. BCG administration produced an initial increase, followed by a depression, of the phytohemagglutinin response of purified blood lymphocytes. An increase in absolute and relative numbers of bursa-equivalent (B)-cells followed BCG administration, concurrent with a decrease in the phytohemagglutinin responsiveness. With adjuvant alone, there was a diminution in phytohemagglutinin response and an increase in number of B-cells; the latter occurred immediately after adjuvant injection and also when the generalized disease appeared. When both BCG and adjvant were present, parallel increases of phytohemagglutinin responsiveness and B-cell numbers resulted. The pattern of tissue localization of radioactively labeled thoracic duct cells from normal or BCG-treated donors given to normal, BCG-treated, adjuvant-injected, and BCG-treated + adjuvant-injected syngeneic recipients indicated significantly greater homing to the thymus and decreased localization to the bone marrow when BCG had been given to either donors or recipients. When labeled thymus cells were used, only the decreased bone marrow localization was noted. These observations suggest that the suppressive effect of BCG may be mediated through modification of the lymphocyte recirculation pattern, possibly resulting from alterations in lymphocyte recognition sites.
机译：通过各种剂量方案给予BCG可抑制大鼠的佐剂疾病。施用BCG可使纯化的血液淋巴细胞的植物血凝素反应产生最初的增加，然后下降。卡介苗给药后，囊样（B）细胞的绝对和相对数量增加，而植物血凝素反应性降低。单独使用佐剂，植物血凝素反应减少，B细胞数量增加。后者在辅助注射后立即发生，也出现在广泛性疾病出现时。当BCG和佐剂同时存在时，导致植物血凝素反应性和B细胞数量平行增加。正常，BCG治疗，佐剂注射，BCG治疗+佐剂注射的同基因受体的正常或BCG治疗供体放射性标记的胸导管细胞的组织定位模式表明，胸腺的归巢显着增加，定位降低当将BCG给予捐赠者或接受者时，骨髓移植到骨髓。当使用标记的胸腺细胞时，仅注意到减少的骨髓定位。这些观察结果表明，卡介苗的抑制作用可能是通过淋巴细胞再循环模式的改变来介导的，这可能是由于淋巴细胞识别位点的改变所致。

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