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首页> 外文期刊>Infection and immunity >A hamster-attenuated, temperature-sensitive mutant of Venezuelan encephalitis virus.
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A hamster-attenuated, temperature-sensitive mutant of Venezuelan encephalitis virus.

机译：委内瑞拉脑炎病毒的仓鼠减毒，温度敏感突变体。

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Pathogenicities of 10 temperature-sensitive mutants of Venezuelan encephalitis virus were studied using the hamster model of human virulence. The parental strain and nine of the temperature-sensitive mutants produced lethal infections in hamsters. Strain ts 126 showed reduced hamster virulence. Deaths with the lethal mutants usually occurred 1 to 3 days later than with parental virus. Nine mutants produced lower levels of viremia than parental virus. Attenuation of ts 126 was related to restriction of viral growth in spleen and probably bone marrow and to absence of the usual pathological lesions in hemopoietic tissues and brain, but was functionally unrelated to temperature sensitivity since temperatures of both normal and infected hamsters remained within the permissive range of the mutant. Deaths did not correlate with titers of the 10 mutants in blood at permissive temperatures or with reversions of four temperature-sensitive mutants to non-temperature-sensitive virus in hamsters.
机译：使用人类毒力的仓鼠模型研究了委内瑞拉脑炎病毒的10个温度敏感突变体的致病性。亲本菌株和九个对温度敏感的突变体在仓鼠中产生致命感染。菌株ts 126显示出降低的仓鼠毒力。致命突变体的死亡通常比亲本病毒的死亡晚1至3天。九个突变体产生的病毒血症水平低于亲本病毒。 ts 126的衰减与脾脏和骨髓中病毒生长的限制有关，以及与造血组织和大脑中没有常见的病理性病变有关，但是由于正常和感染仓鼠的温度都保持在允许范围内，因此在功能上与温度敏感性无关。突变体的范围。在允许的温度下，死亡与血液中10个突变体的滴度没有关系，在仓鼠中，死亡与4个温度敏感突变体向非温度敏感病毒的逆转无关。

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