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首页> 外文期刊>Infection and immunity >In vivo induction of anti-herpes simplex virus immune response by type 1 antigens and lipid A incorporated into liposomes.
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In vivo induction of anti-herpes simplex virus immune response by type 1 antigens and lipid A incorporated into liposomes.

机译：通过1型抗原和掺入脂质体的脂质A在体内诱导抗疱疹单纯性病毒的免疫反应。

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摘要

To establish the requirements for a potential subunit vaccine against herpes simplex virus (HSV), we analyzed the effects on immunogenicity of incorporating detergent-extracted glycoprotein-enriched HSV type 1 (HSV-1) antigens into liposomes alone or with the adjuvant lipid A. Incorporating HSV-1 antigens into liposomes enhanced their immunogenicity for antibody production as detected by radioimmunoassay. Antibody levels to free and liposome-bound antigens were enhanced by administering lipid A as an adjuvant. The maximum immunogenic effect was obtained by incorporating lipid A into liposomes containing the HSV-1 proteins. Such liposomes induced secondary antibody responses higher than those engendered by virus infection. Whereas infectious virus induced cell-mediated immunity detectable by the delayed-type hypersensitivity reactions and cytotoxic T lymphocyte production, none of the liposome preparations induced cell-mediated immunity.
机译：为了确定针对单纯疱疹病毒（HSV）的潜在亚单位疫苗的要求，我们分析了将去污剂提取的富含糖蛋白的HSV 1型（HSV-1）抗原单独或与辅助脂质A掺入脂质体对免疫原性的影响。通过放射免疫测定法将HSV-1抗原掺入脂质体可增强其对抗体生产的免疫原性。通过给予脂质A作为佐剂，可以提高针对游离和脂质体结合抗原的抗体水平。通过将脂质A掺入含有HSV-1蛋白的脂质体中，可获得最大的免疫原性效果。这样的脂质体诱导的二级抗体应答高于病毒感染引起的二级抗体应答。传染性病毒诱导的细胞介导的免疫可通过迟发型超敏反应和细胞毒性T淋巴细胞的产生来检测，而脂质体制剂均未诱导细胞介导的免疫。

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