Vibrio cholerae soluble hemagglutinin/protease is a metalloenzyme.

B A Booth; M Boesman-Finkelstein; R A Finkelstein

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Vibrio cholerae soluble hemagglutinin/protease is a metalloenzyme.

机译：霍乱弧菌可溶血凝素/蛋白酶是一种金属酶。

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A soluble hemagglutinin/protease produced by Vibrio cholerae, which has previously been shown to hydrolyze fibronectin and ovomucin and to cleave lactoferrin and the A subunit of the heat-labile enterotoxin of Escherichia coli, appears to be a zinc metalloendopeptidase. Both its hemagglutinative and protease functions are inhibited by chelating agents, including Zincov, a hydroxamic acid derivative specifically designed to inhibit zinc metalloproteases. Thermolysin, a known zinc-containing protease, also causes hemagglutination of responder chicken erythrocytes. This activity is inhibited by Zincov, which does not affect the hemagglutination activity of trypsin and pronase. The hemagglutinin/protease is active on furylacryloyl-Gly-Leu-NH2, a synthetic substrate for thermolysin and other similar proteases. The hemagglutination activity of V. cholerae-infected or cholera toxin-treated infant rabbit intestinal fluid is not inhibited by Zincov, which suggests that this activity is not due to the hemagglutinin/protease, as formerly proposed.

机译：霍乱弧菌产生的可溶性血凝素/蛋白酶以前已显示能水解纤连蛋白和卵粘蛋白并裂解乳铁蛋白和大肠杆菌的热不稳定肠毒素的A亚基，似乎是金属锌内肽酶。它的血凝功能和蛋白酶功能都受到螯合剂的抑制，包括Zincov，一种专门设计用于抑制锌金属蛋白酶的异羟肟酸衍生物。嗜热菌素，一种已知的含锌蛋白酶，也会引起反应鸡红细胞的血凝反应。 Zincov抑制了这种活性，它不影响胰蛋白酶和链霉蛋白酶的血凝活性。血凝素/蛋白酶对呋喃丙烯酰-Gly-Leu-NH2有活性，后者是嗜热菌蛋白酶和其他类似蛋白酶的合成底物。 Zincov没有抑制霍乱弧菌感染或霍乱毒素治疗的幼兔肠液的血凝活性，这表明该活性不是由于血凝素/蛋白酶引起的，如先前所提出的。

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《Infection and immunity》 |1983年第2期|共6页
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B A Booth; M Boesman-Finkelstein; R A Finkelstein;
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1. Comparative study of Vibrio cholerae non-O1 protease and soluble hemagglutinin with those of Vibrio cholerae O1. [J] . T Honda, B A Booth, M Boesman-Finkelstein, Infection and immunity . 1987,第2期

机译：霍乱弧菌非O1蛋白酶和可溶性血凝素与霍乱弧菌O1的比较研究。
2. In vitro proteolytic processing and activation of the recombinant precursor of El Tor cytolysin/hemolysin (pro-HlyA) of Vibrio cholerae by soluble hemagglutinin/protease of V. cholerae, trypsin, and other proteases. [J] . K Nagamune, K Yamamoto, A Naka, Infection and immunity . 1996,第11期

机译：霍乱弧菌的可溶性血凝素/蛋白酶，胰蛋白酶和其他蛋白酶的体外蛋白水解加工和霍乱弧菌的El Tor溶血素/溶血素的重组前体（pro-HlyA）的活化。
3. Vibrio cholerae hemagglutinin(HA)/protease: An extracellular metalloprotease with multiple pathogenic activities [J] . Benitez Jorge A., Silva Anisia J. Toxicon: An International Journal Devoted to the Exchange of Knowledge on the Poisons Derived from Animals, Plants and Microorganisms . 2016,第Null期

机译：霍乱弧菌血凝素（HA）/蛋白酶：具有多种致病活性的细胞外金属蛋白酶
4. SCREENING METHODOLOGY FOR EVALUATION OF CHITIN DEACETYLASE LIBRARIES: APPLICATION TO VIBRIO CHOLERAE DEACETYLASE MUTANT LIBRARIES FOR ENGINEERED SPECIFICTY [C] . Sergi Pascual, Antoni Planas International Carbohydrate Symposium . 2018

机译：用于评价甲壳素脱乙酰化酶文库的筛选方法：施用霍乱胆拉肽脱乙酰化酶突变体文库的工程特征
5. Regulation of hemagglutinin by flagellar hierarchy in Vibrio cholerae. [D] . Syed, Khalid Ali. 2010

机译：霍乱弧菌中鞭毛等级对血凝素的调节。
6. Vibrio cholerae soluble hemagglutinin/protease is a metalloenzyme. [O] . B A Booth, M Boesman-Finkelstein, R A Finkelstein 1983

机译：霍乱弧菌可溶血凝素/蛋白酶是一种金属酶。
7. In vitro proteolytic processing and activation of the recombinant precursor of El Tor cytolysin/hemolysin (pro-HlyA) of Vibrio cholerae by soluble hemagglutinin/protease of V. cholerae, trypsin, and other proteases [O] . K Nagamune, K Yamamoto, A Naka, 1996

机译：通过可溶性血凝素/蛋白酶，胰蛋白酶，胰蛋白酶和其他蛋白酶的胰胶质蛋白/蛋白酶的弧菌霍乱的重组前体的体外蛋白水解加工和活化的蛋白质溶解剂（Pro-Hlya）

Vibrio cholerae soluble hemagglutinin/protease is a metalloenzyme.

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