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首页> 外文期刊>Infection and immunity >M proteins of group G streptococci isolated from bacteremic human infections.
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M proteins of group G streptococci isolated from bacteremic human infections.

机译：从人类细菌感染中分离出的G组链球菌M蛋白。

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We studied seven strains of group G streptococci isolated from clinically severe bacteremic infections in six intravenous drug abusers. These group G strains multiplied luxuriantly in fresh human blood. On electron microscopy, they exhibited surface fibrillae similar to those observed in M-protein-rich group A streptococci, but they were not serologically M typable with a battery of 39 M antisera. Rabbit antisera raised against two of the group G strains (1618 and 1750) opsonized the homologous but not the heterologous isolates and exhibited type-specific Ouchterlony immunoprecipitin reactions. Moreover, antisera raised against peptic extracts of strain 1750 also promoted phagocytic killing of that strain. Anti-1750 reacted in high titer in an enzyme-linked immunosorbent assay against peptic extracts of the homologous strain; these antibodies were removed by absorption with 1750 cells but not by absorption with heterologous strains. These studies represent, to our knowledge, the first analysis of virulence factors of group G streptococci isolated from invasive human disease. The seven epidemiologically related blood isolates of group G streptococci possess distinct type-specific, antiphagocytic surface virulence factors analogous to the M proteins of group A streptococci.
机译：我们在六名静脉吸毒者中研究了从临床严重细菌感染中分离出的七种G组链球菌菌株。这些G组毒株在新鲜的人血中大量繁殖。在电子显微镜下，它们表现出的表面纤维状结构类似于在富含M蛋白的A组链球菌中观察到的结构，但在血清学上不能用39 M的抗血清进行分型。针对G组毒株中的两个（1618和1750）调配的兔抗血清调理了同源但非异源分离株，并表现出类型特异性Ouchterlony免疫沉淀反应。而且，针对菌株1750的消化性提取物产生的抗血清也促进了对该菌株的吞噬杀死。抗1750在酶联免疫吸附试验中以高滴度对同源菌株的消化液反应;这些抗体是通过1750细胞吸收而除去的，而不是通过异源菌株吸收而除去的。就我们所知，这些研究代表了从侵入性人类疾病中分离出的G组链球菌的致病因子的首次分析。 G组链球菌的七个与流行病学相关的血液分离株具有与A组链球菌M蛋白相似的不同类型特异性抗吞噬表面毒力因子。

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