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Variation in expression of class 1 and class 5 outer membrane proteins during nasopharyngeal carriage of Neisseria meningitidis.

机译:脑膜炎奈瑟氏菌鼻咽运输过程中1类和5类外膜蛋白表达的变化。

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Accidental nasopharyngeal colonization of a laboratory worker by a human disease isolate of Neisseria meningitidis allowed us to examine the variation in expression of outer membrane components and the host humoral response over time. There were quantitative differences in class 1 outer membrane protein expression in nasopharyngeal isolates obtained at different times. Isolates also showed phase variation of all four class 5 outer membrane proteins produced by the colonizing strain. After colonization, we detected new host serum immunoglobulin G antibodies directed against class 1, class 5, and H.8 outer membrane proteins.
机译:实验室工作人员偶然被人脑膜炎奈瑟氏球菌分离出的鼻咽菌落使我们得以研究外膜成分表达和宿主体液反应随时间的变化。在不同时间获得的鼻咽分离物中1类外膜蛋白表达存在定量差异。分离物还显示出由定殖菌株产生的所有四个5类外膜蛋白的相变。定殖后,我们检测到针对1类,5类和H.8外膜蛋白的新宿主血清免疫球蛋白G抗体。

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