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首页> 外文期刊>Infection and immunity >Effects of exogenous agents on the action of Bordetella parapertussis heat-labile toxin on guinea pig skin.
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Effects of exogenous agents on the action of Bordetella parapertussis heat-labile toxin on guinea pig skin.

机译：外源性制剂对百日咳博德特氏菌热不稳定毒素对豚鼠皮肤的作用。

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摘要

Injection of sonic extracts of Bordetella parapertussis into the shaved backs of guinea pigs produced hemorrhagic necrosis, which previously has been attributed to the action of heat-labile toxin. As heat-labile toxin was purified from this crude mixture, its ability to induce hemorrhagic lesions decreased significantly. However, ischemic lesions were apparent after injection of the purified toxin. These lesions, while not hemorrhagic in nature, were marked by erythema surrounded by a region in which the ischemia was apparent. Exogenous agents were found to alter the nature of the skin lesion induced by heat-labile toxin. The lipid A portion of endotoxin in combination with heat-labile toxin caused hemorrhagic lesions surrounded by a ring of ischemia, whereas bovine serum albumin increased the area of erythema. While the nature of lesions induced by heat-labile toxin was affected by exogenous agents, the diameter of ischemia produced by the toxin was found to be independent of the presence of these agents and was linear with toxin dose. These results indicate that induction of hemorrhagic necrosis may not be a reliable indicator of heat-labile toxin activity. Instead, measurement of the ischemic lesion produced by heat-labile toxin may be a useful assay for the toxin.
机译：将豚鼠百日咳博德特氏菌的声音提取物注射到豚鼠剃毛的背部会产生出血性坏死，这以前归因于热不稳定毒素的作用。由于从这种粗混合物中纯化出对热不稳定的毒素，其诱导出血性病变的能力大大降低。但是，注射纯化的毒素后，缺血性损伤很明显。这些病变虽然本质上不是出血性的，但其特征是红斑周围有明显的局部缺血区域。已发现外源性物质可改变热不稳定毒素诱导的皮肤病变的性质。内毒素的脂质A部分与不耐热毒素结合会导致出血性病变，并被局部缺血环包围，而牛血清白蛋白会增加红斑面积。尽管热不稳定毒素诱导的病变性质受外源性药物的影响，但发现该毒素产生的局部缺血的直径与这些药物的存在无关，并且与毒素剂量呈线性关系。这些结果表明出血性坏死的诱导可能不是热不稳定毒素活性的可靠指标。相反，对热不稳定毒素产生的缺血性病变的测量可能是该毒素的有用测定方法。

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