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Induction of circulating group II phospholipase A2 expression in adults with malaria.

机译：诱导成年人疟疾中循环II型磷脂酶A2的表达。

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High levels of interleukin 1 and tumor necrosis factor are found in both cases of malaria and cases of septic shock. Since both interleukin 1 and tumor necrosis factor induce expression of the proinflammatory enzyme phospholipase A2 (PLA2), we examined serum PLA2 levels in 14 adults with malaria. Mean serum PLA2 activity was elevated 40-fold above normal (P less than 0.001). Serum PLA2 activity correlated with PLA2 immunoreactivity (r = 0.987; P less than 0.001) by an enzyme-linked immunosorbent assay specific for human group II PLA2, showing that serum PLA2 in cases of malaria is host derived. This article describes the novel finding of elevated PLA2 levels in cases of malaria, further strengthening the notion that mediators of the host response in cases of malaria are similar to those in cases of septic shock.
机译：在疟疾和败血性休克病例中均发现高水平的白介素1和肿瘤坏死因子。由于白介素1和肿瘤坏死因子均诱导促炎酶磷脂酶A2（PLA2）的表达，我们检查了14名疟疾成年患者的血清PLA2水平。平均血清PLA2活性比正常水平升高40倍（P小于0.001）。通过特异性针对人类II组PLA2的酶联免疫吸附测定，血清PLA2活性与PLA2免疫反应性相关（r = 0.987; P小于0.001），表明疟疾病例中的血清PLA2是宿主来源的。本文介绍了在疟疾病例中PLA2水平升高的新发现，进一步强化了以下观念：疟疾病例中宿主反应的介体与败血性休克病例相似。

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