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首页> 外文期刊>Infection and immunity >Interferon production by human mononuclear leukocytes: differences between respiratory syncytial virus and influenza viruses.
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Interferon production by human mononuclear leukocytes: differences between respiratory syncytial virus and influenza viruses.

机译：人单核白细胞产生的干扰素：呼吸道合胞病毒和流感病毒之间的差异。

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摘要

The ability of respiratory syncytial virus (RSV) to induce interferon production by human mononuclear leukocytes was compared with that of influenza viruses. Cell culture fluids were assayed for interferon activity 1, 3 and 7 days after exposure to RSV or to one of two subtypes of influenza A virus (H0N1 and H3N2). RSV induced interferon production inconsistently and in low titers. Varying the multiplicity of infection did not improve the ability of RSV to induce interferon production. In contrast, influenza viruses were effective inducers of interferon production. Seropositivity to the influenza virus strains was not associated with increased interferon titers. Interferon produced after exposure to RSV or to the influenza viruses was resistant to low pH treatment. The data suggest that interferon production may not be a major component of human immunological defense against RSV infection.
机译：将呼吸道合胞病毒（RSV）诱导人单核白细胞产生干扰素的能力与流感病毒的能力进行了比较。暴露于RSV或暴露于两种A型流感病毒（H0N1和H3N2）之一后1、3和7天，测定细胞培养液的干扰素活性。 RSV不一致且滴度低时诱导干扰素产生。改变感染的多样性并不能提高RSV诱导干扰素产生的能力。相反，流感病毒是干扰素产生的有效诱导剂。对流感病毒株的血清阳性与干扰素效价升高无关。暴露于RSV或流感病毒后产生的干扰素对低pH处理有抵抗力。数据表明，干扰素的产生可能不是人类针对RSV感染的免疫防御的主要组成部分。

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