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首页> 外文期刊>Infection and immunity >Pharmacological modulation of suppressor cell activity in mice with disseminated histoplasmosis.
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Pharmacological modulation of suppressor cell activity in mice with disseminated histoplasmosis.

机译：弥散性组织胞浆病小鼠体内抑制细胞活性的药理调节。

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Indomethacin and cyclophosphamide (CY) were used in an attempt to modify the suppressive effects of spleen cell populations from mice with disseminated histoplasmosis at 1 week of infection. In vitro addition of indomethacin did not alter the depressed plaque-forming cell response to sheep erythrocytes of normal spleen cells cocultured with unfractionated or nylon wool-fractionated spleen cells from infected mice. Likewise, indomethacin given intraperitoneally did not enhance the subnormal in vivo plaque-forming cell response of spleen cells from infected mice. Conversely, 20 mg of CY per kg given intraperitoneally 2 days before or 6 h after the inoculation with Histoplasma capsulatum partially reversed the suppression effected by splenic T cells (nylon wool passed) in vitro, whereas 50 mg of CY per kg given intraperitoneally 6 h after the injection of H. capsulatum ablated suppressor T cell activity in vitro; neither dosage of CY altered the suppression mediated by unseparated or nylon wool-adherent spleen cells. Furthermore, the administration of 50 mg of CY per kg failed to improve the depressed footpad responses of mice infected for 1 week to sheep erythrocytes in sheep erythrocyte-sensitized mice or to histoplasmin. These findings indicate that in experimental disseminated histoplasmosis, suppression effected by splenic T cells can be alleviated by CY; however, there is a persistent immunosuppressor mechanism(s) that cannot be counteracted by either indomethacin or CY.
机译：吲哚美辛和环磷酰胺（CY）用于尝试在感染1周后改变患有弥漫性组织胞浆病的小鼠的脾细胞群的抑制作用。吲哚美辛的体外添加不会改变与感染小鼠未分馏或尼龙毛分馏脾细胞共培养的正常脾细胞对绵羊红细胞的抑制斑块形成细胞反应。同样，腹膜内给予吲哚美辛也不会增强感染小鼠脾细胞的体内亚噬斑形成能力。相反，接种荚膜组织胞浆前2天或之后6小时腹膜内给予每公斤CY 20 mg，部分逆转了体外脾脏T细胞（尼龙羊毛通过）产生的抑制作用，而腹膜内6 h给予每公斤50 mg CY注射荚膜幽门螺杆菌后，在体外消融了抑制性T细胞活性; CY剂量均未改变未分离的或粘附尼龙毛的脾细胞介导的抑制作用。此外，每公斤50 mg CY的给药未能改善感染1周的小鼠对绵羊红细胞致敏小鼠的绵羊红细胞或对组织浆蛋白的沮丧的脚垫反应。这些发现表明，在实验性弥散性组织胞浆菌病中，CY可以减轻脾T细胞的抑制作用。但是，存在一种持续的免疫抑制剂机制，不能被消炎痛或CY所抵消。

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