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首页> 外文期刊>Infection and immunity >Toxoplasma encephalitis in congenic B10 and BALB mice: impact of genetic factors on the immune response.
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Toxoplasma encephalitis in congenic B10 and BALB mice: impact of genetic factors on the immune response.

机译：同基因B10和BALB小鼠中的弓形体脑炎：遗传因素对免疫反应的影响。

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Factors which determine the pathogenesis and course of Toxoplasma encephalitis are poorly understood. In the present study, the influence of genetic factors in congenic B10 and BALB mice of H-2q, H-2k, and H-2b haplotypes was examined following oral infection with a low-virulence strain of Toxoplasma gondii (DX). There were striking differences among these strains. Whereas B10 mice were highly susceptible, BALB mice had a less severe and more protracted disease. In all animals with a fatal outcome, Toxoplasma encephalitis was the cause of death. Within the two congenic groups, the major histocompatibility complex haplotype had a strong impact on the disease. The H-2k haplotype was associated with early death in B10 mice but with a favorable outcome in BALB mice, whereas the reverse was observed for the H-2q haplotype. These findings indicate that genetically determined factors are critically involved in determining the intracerebral immune response and the course of murine toxoplasmosis. Some of these factors appear to be associated with the major histocompatibility complex haplotype, but significant differences between B10 and BALB mice point to a modulating role of additional genetic loci. Immunohistochemical studies and cytokine analyses of cerebrospinal fluid and serum revealed significant differences in the intracerebral immune response between susceptible and resistant strains. A poor outcome was associated with a large number of intracerebral parasites, significant tissue necrosis, a reduced number of intracerebral CD4+ T cells, low intrathecal tumor necrosis factor levels, and, to a lesser extent, a reduced number of intracerebral CD8+ T cells.
机译：决定弓形虫性脑炎发病机理和病程的因素了解甚少。在本研究中，研究了低毒力弓形虫（DX）口服感染后，H-2q，H-2k和H-2b单倍型B10和BALB小鼠的遗传因素的影响。这些菌株之间存在显着差异。 B10小鼠极易感，而BALB小鼠的病情较轻，病程更长。在所有具有致命结果的动物中，弓形虫脑炎是死亡的原因。在这两个同基因组中，主要的组织相容性复合体单倍型对该疾病有强烈影响。 H-2k单倍型与B10小鼠的早期死亡有关，但在BALB小鼠中具有良好的预后，而H-2q单倍型则相反。这些发现表明，遗传确定的因素与确定脑内免疫反应和鼠弓形虫病的病程密切相关。这些因素中的一些似乎与主要的组织相容性复合物单倍型有关，但是B10和BALB小鼠之间的显着差异表明了其他遗传基因座的调节作用。免疫组织化学研究和脑脊液和血清的细胞因子分析表明，敏感和耐药菌株的脑内免疫反应存在显着差异。结果差与大量脑内寄生虫，大量组织坏死，脑内CD4 + T细胞数量减少，鞘内肿瘤坏死因子水平低以及脑内CD8 + T细胞数量减少有关。

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