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首页> 外文期刊>Infection and immunity >Cellular Changes and Apoptosis in the Spleens and Peripheral Blood of Mice Infected with Blood-Stage Plasmodium chabaudi chabaudi AS
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Cellular Changes and Apoptosis in the Spleens and Peripheral Blood of Mice Infected with Blood-Stage Plasmodium chabaudi chabaudi AS

机译：chabaudi chabaudi AS感染了血期的小鼠的脾脏和外周血中的细胞变化和凋亡

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Infection with blood-stage Plasmodium chabaudi chabaudiAS results in splenomegaly, peripheral leukocytosis, and a major activation of the immune system. The frequencies and absolute numbers of T-cell, B-cell, and macrophage populations in spleen and peripheral blood from P. chabaudi-infected BALB/c mice were compared and found to be significantly altered during acute infection. The kinetics of the redistribution of the different cell types in spleen and peripheral blood were different, with T and B cells appearing in the blood when their frequencies and absolute numbers in the spleen were low. The frequency and absolute number of apoptotic cells in the spleen were increased during acute P. chabaudi infection and involved both T cells, B cells, and macrophages. Both Fas and Fas-ligand expression were increased in the spleen. Taken together, our data provide new information on the complex cellular interactions that take place in the immune system during blood-stage malaria infection in a mouse model.
机译：血液阶段的chabaudi chabaudiAS疟原虫感染会导致脾肿大，周围性白细胞增多和免疫系统的主要活化。比较了沙巴氏假单胞菌感染的BALB / c小鼠的脾脏和外周血中T细胞，B细胞和巨噬细胞群体的频率和绝对数量，发现它们在急性感染过程中发生了明显变化。脾脏和外周血中不同细胞类型的重新分布动力学是不同的，当脾脏中的T细胞和B细胞的频率和绝对数较低时，它们就会出现在血液中。急性P. chabaudi感染期间脾脏中凋亡细胞的频率和绝对数量增加，并且涉及T细胞，B细胞和巨噬细胞。 Fas和Fas-配体的表达在脾脏中均增加。两者合计，我们的数据提供了有关小鼠模型在血液阶段疟疾感染期间免疫系统中发生的复杂细胞相互作用的新信息。

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