...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Evaluation of the A/Seal/Mass/1/80 virus in squirrel monkeys.
【24h】

Evaluation of the A/Seal/Mass/1/80 virus in squirrel monkeys.

机译：评估松鼠猴中的A / Seal / Mass / 1/80病毒。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

An influenza A virus isolated from seals [A/Seal/Mass/1/80 (H7N7)] and an isolate of this virus obtained from a human conjunctiva were evaluated for replication and virulence in squirrel monkeys. When the seal virus was administered intratracheally, it replicated in lungs and nasopharynges and induced illness almost to the same extent that a human influenza A virus [A/Udorn/72 (H3N2)] did. In one monkey that died of pneumonia, the seal virus was recovered from spleen, liver, and muscle as well as lung. After conjunctival administration in monkeys, the seal virus replicated to a peak titer in the conjunctivae 30-fold greater than that attained by the human virus, but this difference was not statistically significant. In contrast, the seal virus replicated less well than the human virus in the tracheae and nasopharynges when administered by the conjunctival route. These results indicate that the seal virus can replicate efficiently in primates, that it can spread systemically, and that it might differ from human virus in being able to replicate slightly better in primate conjunctival tissue.
机译：从海豹中分离出的A型流感病毒[A / Seal / Mass / 1/80（H7N7）]和从人结膜获得的该病毒的分离物被评估了在松鼠猴中的复制和毒力。当气管内注射海豹病毒时，它在肺和鼻咽中复制，并几乎与人类甲型流感病毒[A / Udorn / 72（H3N2）]一样诱发疾病。在一只死于肺炎的猴子中，从脾脏，肝脏，肌肉以及肺中回收了海豹病毒。在猴中进行结膜给药后，海豹病毒在结膜中复制的峰值滴度比人病毒达到的峰值高30倍，但这种差异在统计学上并不显着。相反，当通过结膜途径给药时，海豹病毒在气管和鼻咽中的复制不如人类病毒。这些结果表明，海豹病毒可以在灵长类动物中高效复制，可以全身传播，并且它与人病毒的不同之处在于能够在灵长类动物结膜组织中更好地复制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号