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首页> 外文期刊>Infection and immunity >Killing of Aspergillus spores depends on the anatomical source of the macrophage.
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Killing of Aspergillus spores depends on the anatomical source of the macrophage.

机译：杀灭曲霉孢子取决于巨噬细胞的解剖来源。

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To resolve the controversy over the capacity of macrophages to kill or inhibit germination of Aspergillus spores, we compared this function in peritoneal and alveolar macrophages. Alveolar macrophages from rabbits killed 82 to 90% and completely digested 72 to 82% of spores of Aspergillus fumigatus in 30 h. In contrast, peritoneal macrophages could not even inhibit the germination of ingested spores; more than 85% transformed into mycelia within 24 h. Killing by alveolar macrophages was delayed for 3 to 6 h after phagocytosis and was independent of oxidative killing mechanisms and immune activation. The ability of alveolar macrophages to kill Aspergillus spores without modulation by T lymphocytes or the generation of oxygen intermediates points out that concepts built on studies of peritoneal macrophages may be misleading and underscores the importance of studying the role of macrophages in immunity with cells from the appropriate anatomical site.
机译：为了解决有关巨噬细胞杀死或抑制曲霉孢子萌发的能力的争议，我们在腹膜和肺泡巨噬细胞中比较了这种功能。兔子的肺泡巨噬细胞在30小时内杀死了82％至90％的烟曲霉菌，并完全消化了72％至82％的烟曲霉孢子。相反，腹膜巨噬细胞甚至不能抑制摄入的孢子的发芽。超过85％在24小时内转化为菌丝体。吞噬作用后，肺泡巨噬细胞的杀伤被延迟了3至6小时，并且与氧化杀伤机制和免疫激活无关。肺泡巨噬细胞杀灭曲霉孢子孢子而不受T淋巴细胞调节或产生氧气中间体的能力指出，建立在腹膜巨噬细胞研究基础上的概念可能会产生误导，并强调研究巨噬细胞在适当条件下对细胞免疫的作用的重要性。解剖部位。

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