Antigenic characterization of the P6 protein of nontypable Haemophilus influenzae.

T F Murphy; L C Bartos; A A Campagnari; M B Nelson; M A Apicella

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Antigenic characterization of the P6 protein of nontypable Haemophilus influenzae.

机译：不可鉴定流感嗜血杆菌P6蛋白的抗原性表征。

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The purpose of this study was to characterize the degree of antigenic heterogeneity or conservation of a 16,600-dalton outer membrane protein (P6) among strains of nontypable Haemophilus influenzae. Immunization of rabbits with P6 isolated from individual strains resulted in antibody to P6 of all 25 strains tested. The titers of antibody in the sera were similar among the strains. Whole organisms of two strains were used to immunize rabbits, and antibodies were produced to P6 of all strains tested. Monoclonal antibodies developed to P6 from mice immunized with whole cells of three different strains recognized determinants on P6 of all 25 strains tested. Finally, pooled normal human serum contained antibodies to P6 of all 25 strains assayed. These studies indicate that P6 is a highly conserved antigen on the outer membrane of nontypable H. influenzae.

机译：这项研究的目的是表征非典型流感嗜血杆菌菌株之间的抗原异质性程度或16,600道尔顿外膜蛋白（P6）的保守性。用从单个菌株中分离出的P6免疫兔，得到针对所有25个菌株的P6抗体。菌株之间血清中的抗体效价相似。使用两种菌株的完整生物体对兔进行免疫，并产生针对所有测试菌株的P6的抗体。用三种不同菌株的全细胞免疫的小鼠产生的针对P6的单克隆抗体可识别所有25种菌株中P6的决定因素。最终，合并的正常人血清中含有针对所有25种菌株的P6抗体。这些研究表明，P6是不可分型流感嗜血杆菌外膜上高度保守的抗原。

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《Infection and immunity》 |1986年第3期|共6页
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T F Murphy; L C Bartos; A A Campagnari; M B Nelson; M A Apicella;
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中图分类医学免疫学;
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1. Antigenic characterization of the oligosaccharide portion of the lipooligosaccharide of nontypable Haemophilus influenzae. [J] . C C Patrick, A Kimura, M A Jackson, Infection and immunity . 1987,第12期

机译：不可鉴定流感嗜血杆菌脂寡糖寡糖部分的抗原表征。
2. Antigenic diversity of lipooligosaccharides of nontypable Haemophilus influenzae. [J] . A A Campagnari, M R Gupta, K C Dudas, Infection and immunity . 1987,第4期

机译：不可鉴定流感嗜血杆菌脂寡糖的抗原多样性。
3. Outer membrane protein and biotype analysis of pathogenic nontypable Haemophilus influenzae. [J] . S J Barenkamp, R S Munson, D M Granoff Infection and immunity . 1982,第2期

机译：致病性非典型流感嗜血杆菌的外膜蛋白和生物型分析。
4. Epitope analysis of the P6 outer membrane protein of non-typeable Haemophilus influenzae [C] . Yoshiya Ishida, Yusuke Abe, Mitsuru Yanai, International Symposium on Tonsils and Mucosal Barriers of Upper Airways . 2003

机译：非易形血液嗜血杆菌P6外膜蛋白的表位分析
5. Study of two proteins involved in protein disulphide formation: Molecular cloning and characterization of a full-length flavin-dependent monooxygenase from Saccharomyces cerevisiae and preliminary structure analysis on DsbC from Haemophilus influenzae. [D] . Zhang, Man. 2003

机译：研究两种参与蛋白质二硫化物形成的蛋白质：来自酿酒酵母的全长黄素依赖性单加氧酶的分子克隆和表征，以及流感嗜血杆菌中DsbC的初步结构分析。
6. Antigenic characterization of the P6 protein of nontypable Haemophilus influenzae. [O] . T F Murphy, L C Bartos, A A Campagnari, 1986

机译：不可鉴定流感嗜血杆菌P6蛋白的抗原表征。
7. Characterization of antigens from nontypable Haemophilus influenzae recognized by human bactericidal antibodies. Role of Haemophilus outer membrane proteins. [O] . Gnehm, H E, Pelton, S I, Gulati, S, 1985

机译：来自人类细菌抗体识别的不可分型流感嗜血杆菌抗原的表征。嗜血杆菌外膜蛋白的作用。
8. Antimicrobial Susceptibility and Characterization of Outer Membrane Proteins of Haemophilus Ducreyi Isolated in Thailand [R] . Taylor, D. N., Echeverria, P., Hanchalay, S., 1985

机译：泰国嗜血杆菌外膜蛋白的抗菌敏感性和表征

Antigenic characterization of the P6 protein of nontypable Haemophilus influenzae.

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