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首页> 外文期刊>Infection and immunity >Genetic relationships and clonal population structure of serotype 2 strains of Neisseria meningitidis.
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Genetic relationships and clonal population structure of serotype 2 strains of Neisseria meningitidis.

机译：脑膜炎奈瑟氏球菌血清型2菌株的遗传关系和克隆种群结构。

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摘要

Two hundred and thirty-four strains of Neisseria meningitidis, including 94 serotype 2a, 111 serotype 2b, and 19 serotype 2c isolates, together with 10 isolates that were serotyped as 2 with polyvalent antiserum but did not react with monoclonal antibodies, were characterized by the electrophoretic mobilities of 15 metabolic enzymes. Of these enzymes, 14 were polymorphic, and 56 distinctive combinations of alleles at the enzyme loci (electrophoretic types) were identified, among which the mean genetic diversity per locus was 0.413, or about 75% of that recorded for the species N. meningitidis as a whole. Mean genetic diversity among electrophoretic types of the same serotype (2a, 2b, or 2c) was, however, on average, less than half the total species diversity, and no multilocus genotypes were shared between isolates of the different serotypes, which belong to distinctive clonal lineages. Recent temporal changes in the frequencies of recovery of pathogenic strains of serotypes 2a and 2b in South Africa and North America resulted from clone replacement in these populations rather than evolutionary modification of the serotype protein of the initially dominant clones.
机译：234株脑膜炎奈瑟菌菌株，包括94株2a型，111株2b血清型和19株2c血清型分离物，以及10株多价抗血清血清型为2株，但不与单克隆抗体反应的菌株。 15种代谢酶的电泳迁移率。在这些酶中，有14种是多态性的，在酶基因座（电泳类型）上鉴定了56个独特的等位基因组合，其中每个基因座的平均遗传多样性为0.413，约占脑膜炎双球菌物种的75％。整个。但是，相同血清型（2a，2b或2c）的电泳类型之间的平均遗传多样性平均不到物种总多样性的一半，并且在不同血清型的分离株之间没有共享多基因位基因型。克隆谱系。在南非和北美，血清型2a和2b的致病性菌株恢复频率的近期时间变化是由于这些种群中的克隆替换而不是最初占优势的克隆的血清型蛋白的进化修饰引起的。

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