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首页> 外文期刊>Infection and immunity >Protracted anemia associated with chronic, relapsing systemic inflammation induced by arthropathic peptidoglycan-polysaccharide polymers in rats.
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Protracted anemia associated with chronic, relapsing systemic inflammation induced by arthropathic peptidoglycan-polysaccharide polymers in rats.

机译：与关节炎相关的慢性，复发性全身性炎症相关的持续性贫血。

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Mild hypoproliferative anemia with abnormal iron metabolism frequently accompanies chronic inflammation and infection in humans. To determine whether anemia is associated with chronic relapsing arthritis induced by bacterial cell wall polymers, serial determinations of the hematocrit were measured in rats injected intraperitoneally with sonicated peptidoglycan-polysaccharide fragments from group A streptococci. Acute anemia peaked 5 to 10 days after injection, and chronic, spontaneously relapsing anemia persisted for 309 days. 51Cr labeling demonstrated decreased erythrocyte survival, i.e., a half-life of 8.4 days in cell wall-injected rats versus 11.8 days in controls. Erythrocytes were mildly microcytic, and leukocyte counts were elevated during early spontaneous reactivation of arthritis, 15 days after injection of peptidoglycan-polysaccharide. Bone marrow myeloid/erythroid precursor ratios were elevated in arthritic rats (P less than 0.0001). Purified peptidoglycan produced an acute anemia lasting 10 days, while injection of group A streptococcal polysaccharide and mutanolysin-digested cell wall did not affect the hematocrit. The minimal effective dose of peptidoglycan-polysaccharide was 5 micrograms of rhamnose per g (body weight). Serum iron and transferrin levels were decreased in cell wall-injected rats (P less than 0.005) and were closely correlated with hematocrit values and joint inflammatory scores. Stainable iron was increased in the liver, spleen, and mesenteric lymph nodes and unchanged in the bone marrow of cell wall-injected rats. Anemia accompanying chronic, relapsing systemic inflammation induced by peptidoglycan-polysaccharide polymers appears to be an excellent animal model of the anemia of chronic disease.
机译：轻度的增生性贫血，铁代谢异常，通常伴随人类的慢性炎症和感染。为了确定贫血是否与细菌细胞壁聚合物诱发的慢性复发性关节炎有关，在腹膜内注射了来自A组链球菌的超声肽聚糖多糖片段的大鼠中，对血细胞比容进行了系列测定。急性贫血在注射后5至10天达到峰值，而慢性，自发复发性贫血持续309天。 51Cr标记显示红细胞存活率降低，即注射细胞壁的大鼠的半衰期为8.4天，而对照组为11.8天。注射肽聚糖多糖后15天，在关节炎的早期自发激活过程中，红细胞呈轻度微核细胞增多，白细胞计数升高。关节炎大鼠的骨髓髓样/类胡萝卜素前体比率升高（P小于0.0001）。纯化的肽聚糖可产生持续10天的急性贫血，而注射A组链球菌多糖和经溶菌素消化的细胞壁不会影响血细胞比容。肽聚糖多糖的最小有效剂量为每克（体重）5毫克鼠李糖。注射细胞壁的大鼠血清铁和转铁蛋白水平降低（P小于0.005），并且与血细胞比容值和关节炎症评分密切相关。注射了细胞壁的大鼠的肝脏，脾脏和肠系膜淋巴结中的铁含量升高，而骨髓中的含量不变。由肽聚糖-多糖聚合物引起的慢性复发性全身性炎症伴随的贫血似乎是慢性疾病贫血的极好的动物模型。

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