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首页> 外文期刊>Infection and immunity >Recognition of Multiple Antibody Epitopes throughout Borrelia burgdorferi p66, a Candidate Adhesin, in Patients with Early or Late Manifestations of Lyme Disease
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Recognition of Multiple Antibody Epitopes throughout Borrelia burgdorferi p66, a Candidate Adhesin, in Patients with Early or Late Manifestations of Lyme Disease

机译：在莱姆病早期或晚期表现的患者中，对整个伯氏疏螺旋体p66（候选粘附素）的多种抗体表位的识别

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Antibody responses to p66, a candidate integrin ligand ofBorrelia burgdorferi, were studied in 79 patients with early or late manifestations of Lyme disease. The central portion of p66 was previously shown to contain all of the information required for specific recognition of β3-chain integrins, but work by others had suggested that the C-terminal portion of the protein contains a single surface-exposed, immunodominant loop. In examining antibody responses to full-length p66 and to three overlapping fragments of the protein, we found that the majority of Lyme disease patients had immunoglobulin M (IgM) and/or IgG responses to p66 and that, particularly early in the disease, epitopes throughout p66 were recognized. Among patients with later manifestations of the illness, antibody responses to the C-terminal portion of the protein were more prominent. These results demonstrate that Lyme disease patient sera recognize epitopes throughout p66.
机译：在79名患有莱姆病早期或晚期表现的患者中研究了对p66的抗体反应，p66是伯氏疏螺旋体的候选整合蛋白配体。先前显示p66的中央部分包含特异性识别β 3 链整合素所需的所有信息，但其他人的研究表明该蛋白质的C端部分包含单个表面暴露的免疫优势环。在检查针对全长p66和蛋白质三个重叠片段的抗体反应时，我们发现大多数莱姆病患者对p66都有免疫球蛋白M（IgM）和/或IgG反应，尤其是在疾病早期，抗原表位整个p66被识别。在具有该疾病后期表现的患者中，对蛋白质C末端部分的抗体反应更为突出。这些结果表明，莱姆病患者的血清在整个p66都能识别抗原决定簇。

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