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首页> 外文期刊>Infection and immunity >HLA-B27-Transfected (Salmonella Permissive) and HLA-A2-Transfected (Salmonella Nonpermissive) Human Monocytic U937 Cells Differ in Their Production of Cytokines
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HLA-B27-Transfected (Salmonella Permissive) and HLA-A2-Transfected (Salmonella Nonpermissive) Human Monocytic U937 Cells Differ in Their Production of Cytokines

机译:HLA-B27转染的(沙门氏菌允许的)和HLA-A2转染的(沙门氏菌不允许的)人单核U937细胞产生细胞因子的不同

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摘要

The cytokine secretion of the Salmonella-permissive, HLA-B27-positive U937 cells was examined, as it was previously shown that these cells kill Salmonella less efficiently than controls. Salmonella-permissive U937 cells showed upregulated production of interleukin 10 and to a lesser extent tumor necrosis factor alpha. HLA-B27-associated modulation of cytokine responses may have importance in the pathogenesis of reactive arthritis.
机译:检验了沙门氏菌允许的HLA-B27阳性U937细胞的细胞因子分泌,因为先前证明这些细胞杀死沙门氏菌的效率低于对照组。允许沙门氏菌的U937细胞上调白介素10的生成,并在较小程度上降低肿瘤坏死因子α的表达。 HLA-B27相关的细胞因子应答调节可能在反应性关节炎的发病机理中具有重要意义。

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