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首页> 外文期刊>Infection and immunity >Correlation between macrophage activation and bactericidal function and Mycobacterium leprae antigen presentation in macrophages of leprosy patients and normal individuals.
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Correlation between macrophage activation and bactericidal function and Mycobacterium leprae antigen presentation in macrophages of leprosy patients and normal individuals.

机译：麻风病人和正常人巨噬细胞中巨噬细胞活化和杀菌功能与麻风分枝杆菌抗原呈递的相关性。

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摘要

The killing of Mycobacterium leprae by resting and gamma interferon (IFN-gamma)-activated macrophages in normal subjects and leprosy patients was assessed. Resting macrophages from normal individuals demonstrated the ability to kill M. leprae. For macrophages from tuberculoid patients, killing of M. leprae was only achieved in the presence of IFN-gamma, suggesting that initial T-cell activation occurs prior to the killing of M. leprae. In contrast, though activation with IFN-gamma rendered the lepromatous macrophages microbicidal, it failed to induce lymphocyte proliferation, suggesting a defect at either the antigen-presenting cell or the lymphocyte level or both. The concept that T-cell anergy is primarily due to lack of lymphokine generation was ruled out by our results, since responsiveness was restored in only a small proportion of lepromatous patients after exogenous lymphokine addition. In conclusion, this study demonstrated that killing and antigen presentation are two independent events. It appears that the ability of the macrophages per se to kill M. leprae may be of greater importance than lymphocyte-mediated activation for protection against M. leprae infection.
机译：评估了正常受试者和麻风病人中静息和γ-干扰素（IFN-γ）激活的巨噬细胞对麻风分枝杆菌的杀灭作用。来自正常个体的静止巨噬细胞表现出杀死麻风杆菌的能力。对于来自结核患者的巨噬细胞，仅在存在IFN-γ的情况下杀死麻风杆菌，这表明初始的T细胞活化发生在麻风杆菌杀死之前。相反，尽管用IFN-γ激活使麻风巨噬细胞具有杀微生物性，但它未能诱导淋巴细胞增殖，提示抗原呈递细胞或淋巴细胞水平或两者均存在缺陷。我们的结果排除了T细胞无反应主要是由于缺乏淋巴因子生成的概念，因为在添加外源性淋巴因子后，只有一小部分麻风患者恢复了反应能力。总之，这项研究表明杀伤和抗原呈递是两个独立的事件。看来，巨噬细胞本身杀死麻风杆菌的能力可能比淋巴细胞介导的活化对麻风杆菌感染的保护更为重要。

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