Recombinant human tumor necrosis factor alpha promotes adherence of Staphylococcus aureus to cultured human endothelial cells.

A L Cheung; J M Koomey; S Lee; E A Jaffe; V A Fischetti

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Recombinant human tumor necrosis factor alpha promotes adherence of Staphylococcus aureus to cultured human endothelial cells.

机译：重组人肿瘤坏死因子α促进金黄色葡萄球菌对培养的人内皮细胞的粘附。

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Tumor necrosis factor (TNF), a potent inflammatory mediator secreted by monocytes during inflammation, was shown to significantly increase the adherence of Staphylococcus aureus to cultured human umbilical vein endothelial cells in vitro. The stimulatory effect of TNF was dose dependent and was bimodal with respect to time; bacterial adhesion peaked after 4 and 16 h of stimulation with recombinant human TNF-alpha. The ability of TNF-alpha to augment staphylococcal adherence to endothelial cells was contingent upon the presence of plasma factors. Thus, the complex interaction among cytokines (such as TNF), plasma factor(s), and the endothelium serves to modulate bacterial adherence to endothelial cells.

机译：肿瘤坏死因子（TNF）是一种在炎症过程中由单核细胞分泌的有效炎症介质，已显示可显着增加金黄色葡萄球菌对体外培养的人脐静脉内皮细胞的粘附。 TNF的刺激作用是剂量依赖性的，并且在时间上是双峰的。重组人TNF-α刺激4和16小时后，细菌黏附达到高峰。 TNF-α增加葡萄球菌对内皮细胞粘附的能力取决于血浆因子的存在。因此，细胞因子（例如TNF），血浆因子和内皮之间的复杂相互作用用于调节细菌对内皮细胞的粘附。

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《Infection and immunity》 |1991年第10期|共5页
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A L Cheung; J M Koomey; S Lee; E A Jaffe; V A Fischetti;
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中图分类医学免疫学;
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1. Tumor necrosis factor-alpha gene expression and release in cultured human dermal microvascular endothelial cells. [J] . Hoffmann G, Schloesser M, Czechowski M, Experimental dermatology . 2004,第2期

机译：肿瘤坏死因子-α基因在培养的人皮肤微血管内皮细胞中的表达和释放。
2. Downregulation of angiotensin-converting enzyme by tumor necrosis factor-alpha and interleukin-1beta in cultured human endothelial cells. [J] . Saijonmaa O, Nyman T, Fyhrquist F Journal of vascular research . 2001,第4期

机译：在培养的人内皮细胞中，肿瘤坏死因子-α和白介素-1β对血管紧张素转化酶的下调。
3. Tumor necrosis factor alpha acts on cultured human vascular endothelial cells to increase the adhesion of pancreatic cancer cells. [J] . Nozawa F, Hirota M, Okabe A, Pancreas . 2000,第4期

机译：肿瘤坏死因子α作用于培养的人血管内皮细胞，以增加胰腺癌细胞的粘附。
4. The effect of peg on ion exchange purification of recombinant human tumor necrosis factor-alpha [C] . Xiao-Li Feng, Zhi-Qiang Zhang, Chun-Shui Cong, Asia-Pacific biochemical engineering conference;APBIOCHEC'97 . 1997

机译：聚乙二醇对重组人肿瘤坏死因子-α离子交换纯化的影响
5. Intracellular Signal Transduction Mechanisms Regulating the Activation of Human Bronchial Epithelial Cells by Interleukin-17A, Interleukin-27, Tumor Necrosis Factor-alpha and Human Basophils in Inflammatory Diseases [D] . Cao, Ju 2010

机译：调节人白细胞介素17A，白细胞介素27，肿瘤坏死因子-α和人类嗜碱性粒细胞在炎性疾病中激活人支气管上皮细胞的细胞内信号转导机制
6. Recombinant human tumor necrosis factor alpha promotes adherence of Staphylococcus aureus to cultured human endothelial cells. [O] . A L Cheung, J M Koomey, S Lee, 1991

机译：重组人肿瘤坏死因子α促进金黄色葡萄球菌对培养的人内皮细胞的粘附。
7. Recombinant human tumor necrosis factor alpha promotes adherence of Staphylococcus aureus to cultured human endothelial cells [O] . A L Cheung, J M Koomey, S Lee, 1991

机译：重组人肿瘤坏死因子α促进金黄色葡萄球菌的粘附到培养的人内皮细胞
8. Interdependence of the Radioprotective Effects of Human Recombinant Interleukin 1alpha, Tumor Necrosis Factor alpha, Granulocyte Colony-Stimulating Factor, and Murine Recombinant Granulocyte-Macrophage Colony-Stimulating Factor [R] . Neta, R., Oppenheim, J. J., Douches, S. D. 1988

机译：人重组白细胞介素1α，肿瘤坏死因子α，粒细胞集落刺激因子和小鼠重组粒细胞 - 巨噬细胞集落刺激因子的辐射保护作用的相互依赖性

Recombinant human tumor necrosis factor alpha promotes adherence of Staphylococcus aureus to cultured human endothelial cells.

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