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首页> 外文期刊>Infection and immunity >Complete nucleotide sequence of the gene for a surface protein antigen of Streptococcus sobrinus.
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Complete nucleotide sequence of the gene for a surface protein antigen of Streptococcus sobrinus.

机译:链球菌表面蛋白抗原基因的完整核苷酸序列。

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The complete nucleotide sequence of the gene for a cell surface protein antigen (SpaA) of Streptococcus sobrinus MT3791 (serotype g) was determined. The spaA gene consisted of 4,698 bp and coded for a protein of 170,202 Da. A putative signal peptide was found in the amino-terminal end of the protein. A potential promoter sequence and a putative Shine-Dalgarno sequence preceded the open reading frame. Two internal repeating amino acid sequences were present in SpaA. One repeating region, located in the amino-terminal region, was rich in alanine, and the other, located in the central region, was rich in proline. The molecular structure of SpaA was very similar to that of the surface protein antigen of Streptococcus mutans.
机译:确定了链球菌MT3791(血清型g)的细胞表面蛋白抗原(SpaA)的基因的完整核苷酸序列。 spaA基因由4,698 bp组成,编码170,202 Da的蛋白质。在蛋白质的氨基末端发现了一个推定的信号肽。潜在的启动子序列和推定的Shine-Dalgarno序列位于开放阅读框之前。 SpaA中存在两个内部重复氨基酸序列。位于氨基末端区域的一个重复区域富含丙氨酸,而位于中央区域的另一个重复区域富含脯氨酸。 SpaA的分子结构与变形链球菌的表面蛋白抗原非常相似。

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