Morphological changes of cultured endothelial cells after microinjection of toxins that act on the cytoskeleton.

H Müller; C von Eichel-Streiber; E Habermann

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Morphological changes of cultured endothelial cells after microinjection of toxins that act on the cytoskeleton.

机译：微量注射作用于细胞骨架的毒素后，培养的内皮细胞的形态变化。

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Clostridium novyi alpha-toxin and C. difficile toxins A and B (all 200 to 300 kDa) and C. botulinum C2-I toxin (50 kDa) caused a delayed and persistent retraction and rounding of microinjected cells. Microinjected phalloidin acted fast and reversibly. Unlike C2-I toxin, phalloidin passed through the intercellular junctions. Specific antitoxin applied to the medium did not prevent the action of microinjected C. novyi or C. difficile toxin B. Microinjected antitoxin protected against the toxins applied with the medium or injected into the same cells.

机译：诺氏梭菌α-毒素和艰难梭菌毒素A和B（均为200至300 kDa）和肉毒梭菌C2-I毒素（50 kDa）导致显微注射细胞的延迟和持续回缩和舍入。微注射的鬼笔环肽作用迅速且可逆。与C2-I毒素不同，鬼笔环肽通过细胞间连接。施加到培养基上的特定抗毒素不会阻止微注射的诺氏梭菌或艰难梭菌毒素B的作用。微注射的抗毒素可以保护免受介质施加或注射到同一细胞中的毒素的侵害。

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《Infection and immunity》 |1992年第7期|共4页
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H Müller; C von Eichel-Streiber; E Habermann;
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中图分类医学免疫学;
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1. Treatment of cultured human astrocytes and vascular endothelial cells with protein kinase CK2 inhibitors induces early changes in cell shape and cytoskeleton. [J] . Kramerov AA, Golub AG, Bdzhola VG, Molecular and Cellular Biochemistry: An International Journal for Chemical Biology . 2011,第1a2期

机译：用蛋白激酶CK2抑制剂处理培养的人星形胶质细胞和血管内皮细胞可诱导细胞形状和细胞骨架的早期改变。
2. Microinjection of villin into cultured cells induces rapid and long-lasting changes in cell morphology but does not inhibit cytokinesis, cell motility, or membrane ruffling. [J] . Z Franck, M Footer, A Bretscher Journal of cell biology . 1990,第6期

机译：将villin微注射到培养的细胞中会引起细胞形态的快速而持久的变化，但不会抑制胞质分裂，细胞运动或膜起皱。
3. Morphological and biochemical study of cytoskeletal changes in cultured cells after extracellular application of Clostridium novyi alpha-toxin. [J] . A Oksche, R Nakov, E Habermann Infection and immunity . 1992,第7期

机译：胞外应用新孢梭菌α-毒素后培养细胞的细胞骨架变化的形态学和生化研究。
4. EFFECT OF SHEAR STRESS ON THE MORPHOLOGY AND GROWTH OF ENDOTHELIAL CELLS CO-CULTURED WITH SMOOTH MUSCLE CELLS [C] . Thierry Ziegler, R. Wayne Alexander, Robert M. Nerem International Mechanical Engineering Congress and Exposition . 1994

机译：剪切应力对具有平滑肌细胞共培养内皮细胞形态和生长的影响
5. Shear stress-induced morphological adaptations of endothelial cells: Reorganization of cell adhesion complexes and the actin cytoskeleton. [D] . Noria, Sabrena. 2001

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6. Morphological changes of cultured endothelial cells after microinjection of toxins that act on the cytoskeleton. [O] . H Müller, C von Eichel-Streiber, E Habermann 1992

机译：显微注射作用于细胞骨架的毒素后培养的内皮细胞的形态变化。
7. Microinjection of villin into cultured cells induces rapid and long- lasting changes in cell morphology but does not inhibit cytokinesis, cell motility, or membrane ruffling [O] . 1990

机译：将villin微注射到培养的细胞中会引起细胞形态的快速而持久的变化，但不会抑制胞质分裂，细胞运动或膜起皱

Morphological changes of cultured endothelial cells after microinjection of toxins that act on the cytoskeleton.

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