Passive immunization of chickens against Eimeria maxima infection with a monoclonal antibody developed against a gametocyte antigen.

M Wallach; G Pillemer; S Yarus; A Halabi; T Pugatsch; D Mencher

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Passive immunization of chickens against Eimeria maxima infection with a monoclonal antibody developed against a gametocyte antigen.

机译：用针对配子细胞抗原的单克隆抗体对鸡进行最大程度的艾美球虫感染被动免疫。

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Eimeria maxima gametocytes contain two major antigens with molecular masses of 56 and 82 kilodaltons (kDa) which are recognized by convalescent sera from immune chickens. Preparations enriched in these two antigens were used to immunize mice, and several monoclonal antibodies which specifically reacted with the 56-kDa antigen were produced. One of these monoclonal antibodies of the immunoglobulin M subclass, along with immune chicken sera raised against affinity-purified 56- and 82-kDa antigens, was used to passively immunize chicks. On the basis of the parameter of total oocyst output, it was found that these antibodies provided partial protection (40 to 50% inhibition) against E. maxima challenge infections.

机译：艾美球虫最大配子体细胞含有两种主要抗原，分子量分别为56和82千道尔顿（kDa），被免疫鸡的恢复期血清所识别。将富含这两种抗原的制剂用于免疫小鼠，并产生了几种与56-kDa抗原特异性反应的单克隆抗体。这些免疫球蛋白M亚类的单克隆抗体之一，以及针对亲和纯化的56 kDa和82 kDa抗原产生的免疫鸡血清，被用于被动免疫鸡。根据总卵囊产量的参数，发现这些抗体针对最大的大肠杆菌挑战感染提供了部分保护（抑制率为40％至50％）。

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《Infection and immunity》 |1990年第2期|共6页
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M Wallach; G Pillemer; S Yarus; A Halabi; T Pugatsch; D Mencher;
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中图分类医学免疫学;
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1. Passive immunization of chickens against Eimeria maxima infection with a monoclonal antibody developed against a gametocyte antigen. [J] . M Wallach, G Pillemer, S Yarus, Infection and immunity . 1990,第2期

机译：用针对配子细胞抗原的单克隆抗体对鸡进行最大程度的艾美球虫感染被动免疫。
2. Maternal immunization with gametocyte antigens as a means of providing protective immunity against Eimeria maxima in chickens. [J] . M Wallach, A Halabi, G Pillemer, Infection and immunity . 1992,第5期

机译：用配子细胞抗原进行产妇免疫，以提供针对鸡的最大艾美球虫的保护性免疫。
3. Passive immunization with ce:italic>Eimeria tenella/ce:italic> gametocyte antigen 56 (EtGAM56) specific antibodies and active immunization trial with the epitope containing peptide [J] . Stefanie Wiedmer, Alaa Aldin Alnassan, Beate Volke, Veterinary Parasitology . 2017,第期

机译：用＆ ce：斜体> eimeria tenella＆ / ce：斜体>与含有肽的表位的特异性抗体和主动免疫试验
4. Assessment of Profile of Antigenicity and Immunogenicity of Eimeria maxima and Eimeria tenella through Propagative Level and Histopathological Changes in Site Infection for Exploration of Optimal Low Doses of Bivalent Chicken Coccidiosis Live Vaccine [C] . Endang Suprihati, Muchammad Yunus International Conference in One Health . 2018

机译：通过繁殖水平和育龄病理学变化评估eimeria maxima和eimeria tenella的抗原性和免疫原性的概况，以探讨最佳低剂量的二价鸡椰子病活疫苗
5. Phage display selection of recombinant antibodies derived from a chicken immune library against cryopreserved Eimeria tenella sporozoites [D] . Abi Ghanem, Daad Ali 2006

机译：噬菌体展示选择来自鸡免疫文库的针对低温保存的艾美尔球虫孢子体的重组抗体
6. Passive immunization of chickens against Eimeria maxima infection with a monoclonal antibody developed against a gametocyte antigen. [O] . M Wallach, G Pillemer, S Yarus, 1990

机译：用针对配子细胞抗原的单克隆抗体对鸡进行最大程度的艾美球虫感染被动免疫。
7. Maternal transfer of antibodies induced by infection with Eimeria maxima partially protects chickens against challenge with Eimeria tenella [O] . Smith, N. C., Wallach, M., Petracca, M., 2017

机译：由最大艾美球虫感染诱导的抗体的母源转移部分保护鸡免受艾美球虫的攻击
8. Mice are Actively Immunized after Passive Monoclonal Antibody Prophylaxis andRicin Toxin Challenge [R] . Lemley, P. V., Wright, D. C. 1992

机译：在被动单克隆抗体预防和核心毒素攻击后，小鼠被积极免疫

Passive immunization of chickens against Eimeria maxima infection with a monoclonal antibody developed against a gametocyte antigen.

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