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首页> 外文期刊>Infection and immunity >A monoclonal antibody to gamma interferon blocks augmentation of natural killer cell activity induced during systemic cryptococcosis.
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A monoclonal antibody to gamma interferon blocks augmentation of natural killer cell activity induced during systemic cryptococcosis.

机译：抗γ干扰素的单克隆抗体可阻断全身隐球菌病诱导的自然杀伤细胞活性的增强。

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These studies demonstrate that the cytotoxic activity of splenic natural killer (NK) cells is augmented in both nuu and nu/+ mice during systemic cryptococcosis. Both the kinetics and the regulation of NK cell activity differed in Cryptococcus neoformans-infected nuu and nu/+ mice. Greater augmentation was observed following challenge with 10(5) cells than with smaller inocula, and augmented NK cell activity was not always associated with enhanced control of systemic cryptococcosis. Infection with a nonencapsulated strain of C. neoformans induced an early but transient increase in splenic NK cell activity in nuu and nu/+ mice. Injection of capsular polysaccharide induced a transient augmentation of splenic NK cell activity in nu/+ mice but caused a persistent increase in splenic NK cell activity in nuu mice. In vivo treatment with monoclonal antibody to gamma interferon abrogated the augmentation of splenic NK cell activity induced during cryptococcal infections in both nuu and nu/+ mice and enhanced the susceptibility of nu/+ mice to C. neoformans to a greater extent than it did that of nuu mice. These results suggest that gamma interferon is an important mediator of resistance to C. neoformans.
机译：这些研究表明，在系统性隐球菌病中，nu / nu和nu / +小鼠脾脏自然杀伤（NK）细胞的细胞毒活性均增强。在新隐隐球菌感染的nu / nu和nu / +小鼠中，NK细胞活性的动力学和调节均不同。与较小的接种物相比，用10（5）细胞攻击后观察到更大的增强，并且增强的NK细胞活性并不总是与系统性隐球菌病的增强控制相关。在nu / nu和nu / +小鼠中，未包囊的新孢梭菌感染导致脾脏NK细胞活性的早期但短暂的增加。荚膜多糖的注射诱导了nu / +小鼠脾脏NK细胞活性的瞬时增加，但引起了nu / nu小鼠脾脏NK细胞活性的持续增加。用抗γ干扰素的单克隆抗体进行的体内治疗消除了在nu / nu和nu / +小鼠的隐球菌感染过程中诱导的脾NK细胞活性的增强，并在更大程度上增强了nu / +小鼠对新形成梭菌的敏感性。做了nu / nu小鼠。这些结果表明，γ干扰素是对新孢梭菌抗性的重要介体。

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