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首页> 外文期刊>Infection and immunity >Effects of iron limitation on production of a siderophore, outer membrane proteins, and hemolysin and on hydrophobicity, cell adherence, and lethality for mice of Vibrio parahaemolyticus.
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Effects of iron limitation on production of a siderophore, outer membrane proteins, and hemolysin and on hydrophobicity, cell adherence, and lethality for mice of Vibrio parahaemolyticus.

机译：铁限制对副溶血性弧菌小鼠的铁载体，外膜蛋白和溶血素的产生以及疏水性，细胞粘附和致死性的影响。

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摘要

Vibrio parahaemolyticus is one of the most important enteropathogens in Taiwan, Japan, and other coastal regions. The pathogenesis of V. parahaemolyticus disease is not clearly understood. The expression of some factors by V. parahaemolyticus in iron-rich and iron-limited media was analyzed. In the clinical hemolytic strains, the production of a siderophore, two outer membrane proteins (77 and 80 kDa), and thermostable direct hemolysin was significantly enhanced in iron-limited culture, and hemolytic activities, cell hydrophobicity, HEp-2 cell adherence, and lethality for mice were also enhanced. The environmental nonhemolytic strain CCRC12958 that was cultured in iron-limited medium exhibited lethal activity for mice, and other factors except hemolysis were also enhanced like the responses of clinical strains were. These results suggested that a virulent factor(s) of V. parahaemolyticus may be induced or enhanced under iron-limited conditions. The iron-regulated factors reported in this paper may be important in the pathogenesis of V. parahaemolyticus disease.
机译：副溶血性弧菌是台湾，日本和其他沿海地区最重要的肠病原体之一。副溶血性弧菌疾病的发病机理尚不清楚。分析了副溶血弧菌在富含铁和有限铁的培养基中某些因子的表达。在临床溶血菌株中，铁限制培养显着增强了铁载体，两种外膜蛋白（77和80 kDa）和热稳定的直接溶血素的产生，并且溶血活性，细胞疏水性，HEp-2细胞粘附和对小鼠的杀伤力也增强了。在铁限制培养基中培养的环境非溶血性菌株CCRC12958对小鼠表现出致死活性，除溶血作用外，其他因素也有所增强，就像临床菌株的反应一样。这些结果表明，在铁限制条件下可以诱导或增强副溶血性弧菌的毒性因子。本文报道的铁调节因子可能在溶血弧菌的发病机理中很重要。

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