Nucleotide sequence of the ospAB operon of a Borrelia burgdorferi strain expressing OspA but not OspB.

H Eiffert; A Ohlenbusch; W Fehling; H Lotter; R Thomssen

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Nucleotide sequence of the ospAB operon of a Borrelia burgdorferi strain expressing OspA but not OspB.

机译：表达OspA但不表达OspB的伯氏疏螺旋体菌株ospAB操纵子的核苷酸序列。

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摘要

The nucleotide sequence of a 1.6-kb clone containing the gene for outer surface protein A (OspA) of a German strain (GO2) of Borrelia burgdorferi was determined. The deduced amino acid sequence showed a homology of 82% to the OspA molecules from three other B. burgdorferi strains. The best-conserved region was recognized at the 36-amino-terminal amino acids of OspA. OspB could not be identified in the strain investigated, probably because the nucleotide sequence of the ospAB operon prevented expression of the OspB gene.

机译：确定了一个1.6kb克隆的核苷酸序列，该克隆含有Borrelia burgdorferi的德国菌株（GO2）的外表面蛋白A（OspA）的基因。推导的氨基酸序列显示出与来自其他三个B. burgdorferi菌株的OspA分子的82％同源性。在OspA的36个氨基末端氨基酸处发现了最保守的区域。无法在所研究的菌株中鉴定出OspB，这可能是因为ospAB操纵子的核苷酸序列阻止了OspB基因的表达。

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《Infection and immunity》 |1992年第5期|共5页
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H Eiffert; A Ohlenbusch; W Fehling; H Lotter; R Thomssen;
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中图分类医学免疫学;
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5. Borrelia burgdorferi Outer surface protein A (OspA): A tick transmission factor and a Lyme disease vaccine. [D] . Gipson, Clay Livingston. 2004

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6. Nucleotide sequence of the ospAB operon of a Borrelia burgdorferi strain expressing OspA but not OspB. [O] . H Eiffert, A Ohlenbusch, W Fehling, 1992

机译：表达OspA但不表达OspB的伯氏疏螺旋体菌株ospAB操纵子的核苷酸序列。
7. BosR functions as a repressor of the ospAB operon in Borrelia burgdorferi. [O] . Yanlin Shi, Poonam Dadhwal, Xin Li, 2014

机译：BosR作为Borrelia burgdorferi的ospaB操纵子的阻遏物起作用。
8. Use of T7 RNA polymerase to direct expression of outer Surface Protein A (OspA) from the Lyme disease Spirochete, Borrelia burgdorferi [R] . Dunn, John J., Lade, Barbara N. 1991

机译：T7 RNa聚合酶的使用，以引导来自莱姆病螺旋体，伯氏疏螺旋外表面蛋白a（的Ospa）的表达

Nucleotide sequence of the ospAB operon of a Borrelia burgdorferi strain expressing OspA but not OspB.

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