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首页> 外文期刊>Infection and immunity >Apathogenic, intestinal, segmented, filamentous bacteria stimulate the mucosal immune system of mice.
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Apathogenic, intestinal, segmented, filamentous bacteria stimulate the mucosal immune system of mice.

机译：无源，肠道，分段的丝状细菌刺激小鼠的粘膜免疫系统。

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Segmented filamentous bacteria (SFBs) are apathogenic autochthonous bacteria in the murine small intestine that preferentially attach to Peyer's patch epithelium. SFBs have never been cultured in vitro. We have studied the effects of SFBs on the immune system of the host. Mice monoassociated with SFBs were compared with germ-free mice and with mice without SFBs but with a specific-pathogen-free (SPF) gut flora. SFBs versus no microbial flora raised the number of lymphoid cells in the lamina propria of the ileal and cecal mucosa, raised the number of immunoglobulin A (IgA)-secreting cells in the intestinal mucosa, produced elevated IgA titers in serum and intestinal secretions, and enhanced the concanavalin A-induced proliferative responses of mesenteric lymph node cells. The SPF flora had effects similar to but less pronounced than those mediated by SFBs. The results indicate that SFBs stimulate the mucosal immune system to a greater extent than do other autochthonous gut bacteria.
机译：分段丝状细菌（SFB）是鼠类小肠中的无源性自发性细菌，其优先附着在Peyer斑块上皮上。 SFB从未在体外培养过。我们已经研究了SFB对宿主免疫系统的影响。将与SFBs单联的小鼠与无菌小鼠和无SFBs但具有无特定病原体（SPF）肠道菌群的小鼠进行比较。 SFBs与无微生物菌群相比，增加了回肠和盲肠黏膜固有层的淋巴样细胞数量，增加了肠道粘膜中分泌免疫球蛋白A（IgA）的细胞数量，在血清和肠道分泌物中产生了升高的IgA滴度，并且增强了伴刀豆球蛋白A诱导的肠系膜淋巴结细胞的增殖反应。 SPF菌群的作用与SFB介导的作用相似但不那么明显。结果表明，SFBs比其他本地肠细菌更能刺激粘膜免疫系统。

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