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首页> 外文期刊>Infection and immunity >Safety and immunogenicity of meningococcal A and C polysaccharide conjugate vaccine in adults.
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Safety and immunogenicity of meningococcal A and C polysaccharide conjugate vaccine in adults.

机译：成人脑膜炎球菌A和C多糖结合疫苗的安全性和免疫原性。

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A meningococcal vaccine containing group A and C polysaccharides conjugated to CRM197 was evaluated in 50 adults. Vaccinees were entered into one of five groups: 30 adults received a single dose of either 22, 11, or 5.5 micrograms of the conjugated A-C vaccine; 10 received an approved meningococcal vaccine; and 10 received saline injections. Local and systemic reactions to vaccines were recorded, and immune responses were determined. The experimental meningococcal vaccine was well tolerated, with the most frequent reaction being pain at the injection site. Both A and C polysaccharide components of the experimental vaccine were highly immunogenic, and total antibody concentrations 1 month postvaccination were not significantly different from the mean antibody concentrations among adults given the approved meningococcal vaccine. In addition, significant rises in immunoglobulin G, A, and M antibodies to both A and C polysaccharides occurred. Antibody concentrations measured at 6 and 12 months postvaccination had declined but remained significantly higher than prevaccination concentrations. Postvaccination meningococcal group C functional antibody activity increased more than 600-fold for both the polysaccharide and the conjugate vaccines. Further studies of this conjugated meningococcal vaccine are indicated for young children and infants.
机译：在50名成人中评估了包含与CRM197偶联的A组和C组多糖的脑膜炎球菌疫苗。将疫苗分为五组之一：30名成年人接受了22、11或5.5微克结合A-C疫苗的单剂量注射; 10人获得了批准的脑膜炎球菌疫苗; 10例接受了盐水注射。记录对疫苗的局部和全身反应，并确定免疫反应。实验性脑膜炎球菌疫苗耐受性良好，最常见的反应是注射部位的疼痛。实验疫苗的A和C多糖成分均具有高度的免疫原性，接种疫苗后1个月的总抗体浓度与给予批准的脑膜炎球菌疫苗的成年人的平均抗体浓度无显着差异。另外，针对A和C多糖的免疫球蛋白G，A和M抗体显着增加。疫苗接种后6和12个月测得的抗体浓度有所下降，但仍明显高于疫苗接种前的浓度。接种疫苗后，多糖疫苗和结合疫苗的脑膜炎球菌C组功能抗体活性均提高了600倍以上。这种结合的脑膜炎球菌疫苗的进一步研究表明可用于幼儿和婴儿。

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