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首页> 外文期刊>Infection and immunity >Role of gamma-delta T cells in murine Chlamydia trachomatis infection.
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Role of gamma-delta T cells in murine Chlamydia trachomatis infection.

机译：γ-δT细胞在小鼠沙眼衣原体感染中的作用。

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摘要

The role of gamma-delta T cells in host resistance to Chlamydia trachomatis was characterized by using a murine model of pneumonia caused by the mouse pneumonitis agent (MoPn), murine C. trachomatis. At days 3 and 7 after infection, gamma-delta T-cell-deficient knockout mice had significantly higher levels of MoPn in the lungs than did immunologically intact controls. At day 20, paradoxically, gamma-delta T-cell-deficient mice were more resistant to MoPn than were controls. This increased resistance was not due to an increased production of toxic cytokines or interleukin-10 in controls on that day. Gamma-delta T cells play a role in protection early in MoPn infection, but they may be deleterious later in infection, as has been observed in models of salmonella and trypanosome infection.
机译：γ-δT细胞在宿主对沙眼衣原体的抗性中的作用是通过使用小鼠肺炎药（MoPn）鼠沙眼衣原体引起的肺炎的鼠模型来表征的。在感染后第3天和第7天，γ-δT细胞缺陷型敲除小鼠的肺部MoPn水平明显高于免疫原性对照。矛盾的是，在第20天，γ-δT细胞缺陷型小鼠对MoPn的抵抗力要强于对照组。这种增加的抵抗力不是由于当天对照组中毒性细胞因子或白介素10的产生增加。 γ-δT细胞在MoPn感染的早期起保护作用，但如在沙门氏菌和锥虫感染模型中所观察到的那样，它们在感染后期可能有害。

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