The N-terminal half of membrane CD14 is a functional cellular lipopolysaccharide receptor.

S Viriyakosol; T N Kirkland

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The N-terminal half of membrane CD14 is a functional cellular lipopolysaccharide receptor.

机译：膜CD14的N端一半是功能性细胞脂多糖受体。

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CD14, a glycosylphosphatidylinositol-anchored protein on the surface of monocytes, macrophages, and polymorphonuclear leukocytes, is a receptor for lipopolysaccharide (LPS). It was recently reported that an N-terminal 152-amino-acid fragment of soluble CD14 was an active soluble lipopolysaccharide receptor (T. S. -C. Juan, M. J. Kelley, D. A. Johnson, L. A. Busse, E. Hailman, S. D. Wright, and H. S. Lichenstein, J. Biol. Chem. 270:1382-1387, 1995). To determine whether the N-terminal half of the membrane CD14 was a functional LPS receptor on the cell membrane, we engineered a chimeric gene coding for amino acids 1 to 151 of CD14 fused to the C-terminal region of decay-accelerating factor and expressed it in Chinese hamster ovary cells and 70Z/3 cells. We found that the chimeric, truncated CD14 is a fully functional LPS receptor in both cell lines.

机译：CD14是单核细胞，巨噬细胞和多形核白细胞表面上糖基磷脂酰肌醇的固定蛋白，是脂多糖（LPS）的受体。最近报道，可溶性CD14的N末端152个氨基酸片段是活性的可溶性脂多糖受体（TS -C。Juan，MJ Kelley，DA Johnson，LA Busse，E.Hailman，SD Wright和HS Lichenstein ，J.Biol.Chem.270：1382-1387，1995）。为了确定膜CD14的N端一半是否是细胞膜上的功能性LPS受体，我们设计了一个嵌合基因，编码嵌合在衰变加速因子C端区域的CD14的1至151位氨基酸，并表达在中国仓鼠卵巢细胞和70Z / 3细胞中。我们发现，嵌合的，截短的CD14在两种细胞系中都是功能齐全的LPS受体。

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《Infection and immunity》 |1996年第2期|共4页
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S Viriyakosol; T N Kirkland;
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中图分类医学免疫学;
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1. Membrane-anchored forms of lipopolysaccharide (LPS)-binding protein do not mediate cellular responses to LPS independently of CD14. [J] . Tapping RI, Orr SL, Lawson EM, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1999,第9期

机译：膜固定形式的脂多糖（LPS）结合蛋白不介导对CDS的LPS的细胞反应。
2. The bacterial endotoxin lipopolysaccharide has the ability to target the brain in upregulating its membrane CD14 receptor within specific cellular populations. [J] . Lacroix S, Feinstein D, Rivest S Brain pathology . 1998,第4期

机译：细菌内毒素脂多糖具有靶向大脑的能力，可上调特定细胞群体内的膜CD14受体。
3. Lipopolysaccharide needs soluble CD14 to interact with TLR4 in human monocytes depleted of membrane CD14 [J] . Moreno C, Merino J, Ramirez N, Microbes and infection . 2004,第11期

机译：脂多糖需要可溶性CD14才能与耗尽膜CD14的人类单核细胞中的TLR4相互作用
4. Towards Simulations of Outer Membrane Proteins in Lipopolysaccharide Membranes [C] . T. A. Soares, T. P. Straatsma International Conference of Computational Methods in Sciences and Engineering 2007(ICCMSE 2007); 20070925-30; Corfu(GR) . 2007

机译：模拟脂多糖膜中的外膜蛋白
5. Cell surface receptor CD14 is necessary for lipopolysaccharide recognition but is not sufficient for ligand-specific activation of proinflammatory responses. [D] . Savedra, Ricardo, Jr. 1997

机译：细胞表面受体CD14对于脂多糖识别是必需的，但不足以对促炎反应的配体特异性活化。
6. The N-terminal half of membrane CD14 is a functional cellular lipopolysaccharide receptor. [O] . S Viriyakosol, T N Kirkland 1996

机译：膜CD14的N端一半是功能性细胞脂多糖受体。
7. The N-terminal half of membrane CD14 is a functional cellular lipopolysaccharide receptor [O] . S Viriyakosol, T N Kirkland 1996

机译：膜CD14的N-末端半部是功能性细胞脂多糖受体
8. Lipopolysaccharide-Induced Protein Tyrosine Phosphorylation in Human Macrophagesis Mediated by CD14. (Reannouncement with New Availability Information) [R] . Weinstein, S. L., June, C. H. 1993

机译：CD14介导的人巨噬细胞脂多糖诱导蛋白酪氨酸磷酸化。（重新公布新的可用性信息）

The N-terminal half of membrane CD14 is a functional cellular lipopolysaccharide receptor.

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