• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Staphylocidal action of thrombin-induced platelet microbicidal protein is not solely dependent on transmembrane potential.
【24h】

Staphylocidal action of thrombin-induced platelet microbicidal protein is not solely dependent on transmembrane potential.

机译：凝血酶诱导的血小板杀微生物蛋白的杀真菌作用不仅取决于跨膜电位。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Thrombin-induced platelet microbicidal protein (tPMP) is a small, cationic, antimicrobial peptide released from rabbit platelets when stimulated with thrombin. We studied the relationship between staphylococcal transmembrane potential (delta psi) and tPMP staphylocidal activity. A genetically related pair of Staphylococcus aureus strains, 6850 and JB1, which differ in delta psi generation (-143 and -97 mV, respectively) were used. Mutant JB-1 was substantially less susceptible to tPMP than the parental strain, 6850. Menadione supplementation, which normalized the delta psi of strain JB-1, did not restore JB-1 tPMP susceptibility. These findings suggest that the staphylocidal activities of tPMP require factors other than or in addition to an intact delta psi.
机译：凝血酶诱导的血小板杀微生物蛋白（tPMP）是凝血酶刺激后从兔血小板中释放出来的一种小型阳离子抗微生物肽。我们研究了葡萄球菌跨膜电位（Δpsi）和tPMP杀虫活性之间的关系。使用了遗传相关的一对金黄色葡萄球菌菌株6850和JB1，它们的Δpsi生成不同（分别为-143和-97 mV）。与亲本菌株6850相比，突变JB-1对tPMP的敏感性要低得多。甲萘醌补充剂使菌株JB-1的Δpsi正常化，并未恢复JB-1对tPMP的敏感性。这些发现表明，tPMP的杀菌活性除了完整的psi外，还需要其他因素。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号