Reduced virulence of Candida albicans MKC1 mutants: a role for mitogen-activated protein kinase in pathogenesis.

R Diez-Orejas; G Molero; F Navarro-García; J Pla; C Nombela; M Sanchez-Pérez

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Reduced virulence of Candida albicans MKC1 mutants: a role for mitogen-activated protein kinase in pathogenesis.

机译：降低白色念珠菌MKC1突变体的毒力：促分裂原活化蛋白激酶在发病机理中的作用。

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Deletion of the Candida albicans mitogen-activated protein kinase MKC1 gene gave rise to viable cells whose cell integrity was affected (F. Navarro-García, M. Sánchez, J. Pla, and C. Nombela, Mol. Cell. Biol. 15:2197-2206, 1995). In an experimental infection system using a murine model, the C. albicans mkc1 delta/mkc1 delta strain was found to be less pathogenic than the parental strain, as show the different time of survival, percentage of mortality, fungal load in the most representative organs, and histological analysis. This is the first study that shows the involvement of the cell integrity pathway in the pathogenicity of a dimorphic fungus.

机译：删除白色念珠菌促分裂原激活的蛋白激酶MKC1基因后，产生了存活细胞，其细胞完整性受到影响（F.Navarro-García，M。Sánchez，J。Pla和C. Nombela，Mol。Cell。Biol。15： 2197-2206，1995）。在使用鼠模型的实验感染系统中，发现白色念珠菌mkc1 delta / mkc1 delta菌株的病原性低于亲本菌株，因为它显示了最有代表性的器官的不同生存时间，死亡率，真菌载量，以及组织学分析。这是第一项显示细胞完整性途径参与双态性真菌致病性研究。

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《Infection and immunity》 |1997年第2期|共5页
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R Diez-Orejas; G Molero; F Navarro-García; J Pla; C Nombela; M Sanchez-Pérez;
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1. Functional characterization of the MKC1 gene of Candida albicans, which encodes a mitogen-activated protein kinase homolog related to cell integrity. [J] . F Navarro-García, M Sánchez, J Pla, Molecular and Cellular Biology . 1995,第4期

机译：白色念珠菌的MKC1基因的功能表征，该基因编码与细胞完整性有关的有丝分裂原激活的蛋白激酶同源物。
2. Role of the Mitogen-Activated Protein Kinase Hog1p in Morphogenesis and Virulence of Candida albicans [J] . R. Alonso-Monge, F. Navarro-García, G. Molero, Journal of bacteriology . 1999,第10期

机译：丝裂原活化蛋白激酶Hog1p在白色念珠菌的形态发生和毒力中的作用
3. A role for the MAP kinase gene MKC1 in cell wall construction and morphological transitions in Candida albicans [J] . Federico Navarro-García, Rebeca Alonso-Monge, Hortensia Rico, Microbiology . 1998,第2期

机译：念珠菌墙壁构建的地图激酶基因MkC1的作用和念珠菌汉语念珠菌的形态转变
4. Activation of Mitogen-activated Protein Kinases and Protein Kinase B/akt Signaling By Oxidative Stress in Vascular Smooth Muscle Cells: involvement in Vascular Pathophysiology [C] . Ashok K. Srivastava, Nihar R. Pandey, Antoine Blanc International Society for Heart Research.Congress . 2004

机译：血管平滑肌细胞氧化应激激活丝裂剂活化蛋白激酶和蛋白激酶B / Akt信号传导：血管病理生理学中的参与
5. The effect of inorganic lead on DNA synthesis in 1321N1 human astrocytoma cells: Roles of protein kinase C and mitogen-activated protein kinases. [D] . Lu, Hailing. 2001

机译：无机铅对1321N1人星形细胞瘤细胞DNA合成的影响：蛋白激酶C和促分裂原活化蛋白激酶的作用。
6. Reduced virulence of Candida albicans MKC1 mutants: a role for mitogen-activated protein kinase in pathogenesis. [O] . R Diez-Orejas, G Molero, F Navarro-García, 1997

机译：降低白色念珠菌MKC1突变体的毒力：促丝裂原激活的蛋白激酶在发病机理中的作用。
7. Reduced virulence of Candida albicans MKC1 mutants: a role for mitogen-activated protein kinase in pathogenesis [O] . R Diez-Orejas, G Molero, F Navarro-García, 1997

机译：降低念珠菌蛋白MKC1突变体的毒力：发病机制中丝裂剂活化蛋白激酶的作用
8. Protective Role of PI3-kinase/Akt/eNOS Signaling in Mechanical Stress Through Inhibition of p38 Mitogen-Activated Protein Kinase in Mouse Lung [R] . Peng, X., Damarla, M., Skirball, J., 2010

机译：pI3-激酶/ akt / eNOs信号通过抑制小鼠肺中p38丝裂素活化蛋白激酶对机械应激的保护作用

Reduced virulence of Candida albicans MKC1 mutants: a role for mitogen-activated protein kinase in pathogenesis.

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