Human CD8+ T Cells Specific forMycobacterium tuberculosis Secreted Antigens in Tuberculosis Patients and Healthy BCG-Vaccinated Controls in The Gambia

Steven M. Smith; Michèl R. Klein; Adam S. Malin; Jackson Sillah; Kris Huygen; Peter Andersen; Keith P. W. J. McAdam; Hazel M. Dockrell

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Human CD8+ T Cells Specific forMycobacterium tuberculosis Secreted Antigens in Tuberculosis Patients and Healthy BCG-Vaccinated Controls in The Gambia

机译：冈比亚结核病患者的结核分枝杆菌特异的人类CD8 + T细胞和冈比亚健康BCG疫苗接种的对照

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Intracellular flow cytometry analysis of perforin production by CD8+ T cells showed levels were greatly reduced in tuberculosis (TB) patients compared to healthy controls. Reduced cytotoxic-T-lymphocyte activity was also obtained with CD8+T cells from TB patients compared to healthy controls in The Gambia. A change in antigen recognition was noted between the two groups of donors: in addition to recognition of Ag85A and Ag85B, as seen in healthy donors, a prominent ESAT-6 response was found in TB patients.

机译：细胞内流式细胞术分析CD8 + T细胞产生的穿孔素表明，与健康对照组相比，结核病（TB）患者的水平显着降低。与冈比亚健康对照相比，来自结核病患者的CD8 + T细胞还降低了细胞毒性T淋巴细胞的活性。注意到两组供体之间的抗原识别有所变化：除了在健康供体中看到的对Ag85A和Ag85B的识别外，在结核病患者中发现了显着的ESAT-6反应。

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《Infection and immunity》 |2000年第12期|共5页
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Steven M. Smith; Michèl R. Klein; Adam S. Malin; Jackson Sillah; Kris Huygen; Peter Andersen; Keith P. W. J. McAdam; Hazel M. Dockrell;
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1. Human CD8+ T Cells Specific forMycobacterium tuberculosis Secreted Antigens in Tuberculosis Patients and Healthy BCG-Vaccinated Controls in The Gambia [J] . Steven M. Smith, Michèl R. Klein, Adam S. Malin, Infection and immunity . 2000,第12期

机译：冈比亚结核病患者的结核分枝杆菌特异的人类CD8 + T细胞和冈比亚健康BCG疫苗接种的对照
2. CD85/LIR-1/ILT2 and CD152 (Cytotoxic T Lymphocyte Antigen 4) Inhibitory Molecules Down-Regulate the Cytolytic Activity of Human CD4+ T-Cell Clones Specific forMycobacterium tuberculosis [J] . Andrea Merlo, Daniele Saverino, Claudya Tenca, Infection and immunity . 2001,第10期

机译：CD85 / LIR-1 / ILT2和CD152（细胞毒性T淋巴细胞抗原4）抑制分子下调结核分枝杆菌特异的人类CD4 + T细胞克隆的细胞裂解活性
3. Pulmonary mononuclear cell responses to antigens of Mycobacterium tuberculosis in healthy household contacts of patients with active tuberculosis and healthy controls from the community. [J] . Schwander SK, Torres M, Carranza C-C, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2000,第3期

机译：在患有活动性结核病的患者和社区健康对照的健康家庭接触者中，肺单核细胞对结核分枝杆菌抗原的反应。
4. Mycobacterium tuberculosis Antigen-Specific IL-2R and IP-10 Expression Changes in Chronic Obstructive Pulmonary Disease Patients with in Latent Tuberculosis Infection [C] . Sungyong Bong, Sunghyun Kim, Joo Hwan Hwang, International Molecular Medicine Tri-Conference. . 2016

机译：结核分枝杆菌抗原特异性IL-2R和IP-10表达变化慢性阻塞性肺病患者潜在结核病感染
5. Characterization of gammadelta T cells relevant for protective tuberculosis immunity: T cell specificity, antigen identification and mechanisms of inhibition. [D] . Spencer, Charles T. 2008

机译：与保护性结核免疫相关的γδT细胞的表征：T细胞特异性，抗原鉴定和抑制机制。
6. Note: Human CD8+ T Cells Specific for Mycobacterium tuberculosis Secreted Antigens in Tuberculosis Patients and Healthy BCG-Vaccinated Controls in The Gambia [O] . Steven M. Smith, Michèl R. Klein, Adam S. Malin, 2000

机译：注意：冈比亚结核病患者的结核分枝杆菌特异的人类CD8 + T细胞和冈比亚接种BCG疫苗的健康对照
7. Human CD8+ T Cells Specific for Mycobacterium tuberculosis Secreted Antigens in Tuberculosis Patients and Healthy BCG-Vaccinated Controls in The Gambia [O] . Smith, Steven M., Klein, Michèl R., Malin, Adam S., 2000

机译：冈比亚结核病患者的结核分枝杆菌特异的人类CD8 + T细胞和冈比亚健康BCG疫苗接种的对照
8. Effect of Human Prealbumin Fraction with Thymic Hormone Activity on the Mononuclear Cells of Coccidioidomycosis Patients and Tuberculosis Patients [R] . Williams, P. L., Brummer, E., Stevens, D. A. 1984

机译：人前白蛋白组分与胸腺激素活性对球孢子菌病和结核病患者单核细胞的影响

Human CD8+ T Cells Specific forMycobacterium tuberculosis Secreted Antigens in Tuberculosis Patients and Healthy BCG-Vaccinated Controls in The Gambia

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