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首页> 外文期刊>Infection and immunity >Structure of Campylobacter jejuni Lipopolysaccharides Determines Antiganglioside Specificity and Clinical Features of Guillain-Barré and Miller Fisher Patients
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Structure of Campylobacter jejuni Lipopolysaccharides Determines Antiganglioside Specificity and Clinical Features of Guillain-Barré and Miller Fisher Patients

机译：空肠弯曲菌脂多糖的结构决定了格林-巴雷和米勒·费舍尔患者的抗神经节苷脂特异性和临床特征

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摘要

Ganglioside mimicry in the lipopolysaccharide (LPS) fraction of Campylobacter jejuni isolated from Guillain-Barré syndrome (GBS) and Miller Fisher syndrome (MFS) patients was compared with isolates from patients with an uncomplicated enteritis. The antibody response to C. jejuni LPS and gangliosides in neuropathy patients and controls was compared as well. LPS from GBS and MFS-associated isolates more frequently contained ganglioside-like epitopes compared to control isolates. Almost all neuropathy patients showed a strong antibody response against LPS and multiple gangliosides in contrast to enteritis patients. Isolates from GBS patients more frequently had a GM1-like epitope than isolates from MFS patients. GQ1b-like epitopes were present in all MFS-associated isolates and was associated with anti-GQ1b antibody reactivity and the presence of oculomotor symptoms. These results demonstrate that the expression of ganglioside mimics is a risk factor for the development of post-Campylobacter neuropathy. This study provides additional evidence for the hypothesis that the LPS fraction determines the antiganglioside specificity and clinical features in post-Campylobacter neuropathy patients.
机译：比较了从格林-巴利综合征（GBS）和米勒·费雪综合症（MFS）患者中分离出的空肠弯曲杆菌（Campylobacter jejuni）脂多糖（LPS）部分中的神经节苷脂模拟物与单纯性肠炎患者的分离物进行了比较。抗体对 C的反应。还比较了神经病变患者和对照中的空肠脂多糖和神经节苷脂。与对照分离株相比，来自GBS和MFS相关分离株的LPS含有神经节苷脂样表位的频率更高。与肠炎患者相反，几乎所有神经病患者均表现出针对LPS和多种神经节苷脂的强抗体反应。来自GBS患者的分离株比来自MFS患者的分离株更常见具有GM1样表位。 GQ1b样抗原决定簇存在于所有与MFS相关的分离物中，并与抗GQ1b抗体反应性和动眼症状有关。这些结果表明神经节苷脂模拟物的表达是弯曲杆菌神经病发展的危险因素。这项研究为以下假设提供了进一步的证据：LPS分数决定了<弯曲>弯曲杆菌神经病患者的抗神经节苷脂特异性和临床特征。

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