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首页> 外文期刊>Infection and immunity >Passive immunity to bovine rotavirus in newborn calves fed colostrum supplements from immunized or nonimmunized cows.
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Passive immunity to bovine rotavirus in newborn calves fed colostrum supplements from immunized or nonimmunized cows.

机译：用免疫或未免疫牛的初乳补充品喂养的新生牛犊对牛轮状病毒的被动免疫。

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Colostrum was collected and pooled from each of five cows in three experimental groups: group I cows received intramuscular and intramammary inoculations of adjuvanted modified live Ohio Agricultural Research and Development Center rotavirus vaccine; group II cows were injected intramuscularly with a commercial modified-live rota-coronavirus vaccine; and group III cows were uninoculated controls. Pooled colostrum from group I cows had higher (P less than 0.05) enzyme-linked immunosorbent assay (ELISA) immunoglobulin G (IgG1) and virus neutralization (VN) rotavirus antibody titers (ELISA IgG1 = 2,413,682; VN = 360,205) than did colostrum from group II (ELISA IgG1 = 8,192; VN = 4,395) or group III cows (ELISA IgG1 = 5,916; VN = 2,865). The antibody titers of these last two colostrum pools did not differ (P greater than 0.05). Samples of these colostrum pools were fed as daily supplements (percent [vol/vol] in cow's milk infant formula) to 28 newborn, unsuckled, antibody-seronegative, male Holstein calves. Eight calves received no supplemental colostrum. The calves were orally challenged with virulent bovine rotavirus and monitored daily for diarrhea and fecal rotavirus shedding. Diarrhea and rotavirus shedding occurred in the eight calves fed no supplemental colostrum and persisted longest in this group. The pooled colostrum from group I cows protected eight of eight calves from both rotavirus diarrhea and shedding when fed as a 1% supplement. The pooled colostrum from neither group II nor group III cows protected 12 other calves against rotavirus diarrhea or shedding when fed at the same concentration (1%). Six rotavirus-challenged calves fed 0.1% supplemental colostrum from group I cows and two calves fed 10 and 50% supplemental colostrum from control cows displayed partial passive immunity, exemplified by delayed onset and shortened duration of rotavirus-associated diarrhea and virus shedding.
机译：从三个实验组的五头母牛的每头牛中收集和收集初乳：第一组母牛肌肉内和乳房内接种了改良的活俄亥俄农业研究与发展中心轮状病毒疫苗;第二组奶牛肌肉内注射了改良的活轮状冠状病毒疫苗。第三组奶牛是未接种的对照。第一组奶牛的初乳的酶联免疫吸附测定（ELISA）免疫球蛋白G（IgG1）和病毒中和（VN）轮状病毒抗体滴度（ELISA IgG1 = 2,413,682; VN = 360,205）更高（P小于0.05）组II（ELISA IgG1 = 8,192; VN = 4,395）或组III奶牛（ELISA IgG1 = 5,916; VN = 2,865）。最后两个初乳库的抗体滴度没有差异（P大于0.05）。将这些初乳库的样品作为每日补充品（牛乳婴儿配方食品中的[vol / vol]百分比）喂给28只新生的，未吸吮的，抗体血清阴性的雄性荷斯坦犊牛。八头小牛没有补充初乳。用强力牛轮状病毒口服攻击小牛，并每天监测腹泻和粪便轮状病毒的脱落情况。在没有补充初乳的八头犊牛中出现腹泻和轮状病毒脱落，并且在该组中持续时间最长。当饲喂1％的补品时，来自第I组奶牛的初乳汇集起来可以保护八头小牛中的八头免受轮状病毒腹泻和脱落的影响。当以相同的浓度（1％）喂养时，来自第II组和第III组奶牛的初乳的混合均不能保护其他12头小牛轮状病毒腹泻或脱落。六只轮状病毒攻击的犊牛饲喂了来自第I组奶牛的0.1％补充初乳，而两只牛犊则饲喂了对照乳牛的分别为10％和50％的初乳，表现出部分被动免疫性，表现为轮状病毒相关的腹泻和病毒感染的发作延迟，持续时间缩短。

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