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首页> 外文期刊>Infection and immunity >Influence of dose and route of Mycobacterium lepraemurium inoculation on the production of interleukin 1 and interleukin 2 in C57BL/6 mice.
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Influence of dose and route of Mycobacterium lepraemurium inoculation on the production of interleukin 1 and interleukin 2 in C57BL/6 mice.

机译：接种分枝杆菌的剂量和途径对C57BL / 6小鼠白介素1和白介素2产生的影响。

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摘要

Groups of C57BL/6 mice were infected either intravenously or subcutaneously with 10(5) or 10(8) Mycobacterium lepraemurium cells, and the ability of their splenic macrophages and T-cells to produce, respectively, interleukin 1 on lipopolysaccharide stimulation and interleukin 2 on concanavalin A stimulation was assessed during the course of infection. In all groups of infected mice, interleukin 1 production remained unaffected during the entire observation period, whereas interleukin 2 activity decreased as the infection progressed. Heavily infected mice (10(8) M. lepraemurium cells) showed an earlier and stronger deficiency interleukin 2 production by concanavalin A-stimulated spleen cells than did mice infected with a lower dose (10(5) bacilli), without detectable influence by the route of inoculation. In mice receiving 10(5) bacilli, minor differences were seen according to the route of infection, with a slight delay in interleukin 2 decrease in mice injected intravenously. In subcutaneously inoculated mice, the failure of spleen cells to produce interleukin 2 after concanavalin A stimulation did not correlate with the number of bacilli developing in the spleen, suggesting the existence of suppressor mechanisms acting at a distance from the site of inoculation.
机译：每组C57BL / 6小鼠静脉或皮下感染了10（5）或10（8）支原体分枝杆菌细胞，其脾巨噬细胞和T细胞分别产生白介素1刺激脂多糖和白介素2的能力刀豆蛋白在感染过程中被评估为刺激。在所有受感染小鼠组中，在整个观察期内，白细胞介素1的产生均不受影响，而白细胞介素2的活性随着感染的进行而降低。重度感染的小鼠（10（8）麻风杆菌细胞）与伴有较低剂量（10（5）杆菌）的小鼠相比，伴刀豆球蛋白A刺激的脾细胞显示出更早，更强的缺陷白细胞介素2产生，而没有受到可检测的影响。接种途径。在接受10（5）杆菌的小鼠中，根据感染途径观察到细微差异，静脉注射小鼠的白介素2降低略有延迟。在皮下接种的小鼠中，伴刀豆球蛋白A刺激后脾细胞未能产生白介素2与脾脏中形成的细菌数量无关，这表明在距接种部位一定距离处存在抑制机制。

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