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首页> 外文期刊>Infection and immunity >Effect of peroral immunization of humans with Streptococcus mutans on induction of salivary and serum antibodies and inhibition of experimental infection.
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Effect of peroral immunization of humans with Streptococcus mutans on induction of salivary and serum antibodies and inhibition of experimental infection.

机译：变形链球菌对人的经口免疫对唾液和血清抗体的诱导及实验性感染的抑制作用。

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Naturally occurring antibodies reactive with Streptococcus mutans whole cells were assayed in whole saliva, parotid saliva, and blood samples collected from eight human volunteers. The levels and serotypes of indigenous S. mutans in plaque and whole saliva samples were also determined. After baseline sampling the teeth were cleaned and the subjects were inoculated with streptomycin-resistant S. mutans strains Ingbritt (serotype c) and OMZ65 (serotype g). The level of implantation and duration of colonization were determined in plaque and saliva, and antibodies reactive with these strains were monitored in saliva and serum. After the implanted bacteria were shed, the subjects wee immunized by the daily ingestion of an enteric-coated capsule containing 25 mg of Formalin-killed, freeze-dried OMZ65 cells for 3 days and inoculation was repeated. The levels of antibodies and of implantation and the duration of colonization were monitored as before. One month after the bacteria could no longer be detected, the immunization and inoculation cycle was repeated except that the subjects were immunized for 7 days. Five of the eight subjects were successfully colonized by strains Ingbritt and OMZ65. The remaining three did not become colonized with either strain. Strain OMZ65 implanted at a higher level than did strain Ingbritt. Oral immunization did not result in a detectable antibody response in saliva or serum to whole bacterial cells. However, after both the first and second immunizations there were marked reductions in the peak levels of infection and the duration of colonization of both OMZ65 and Ingbritt.
机译：在八名人类志愿者的全唾液，腮腺唾液和血液样本中分析了与变形链球菌全细胞具有反应性的天然存在的抗体。还确定了斑块和整个唾液样品中的土著变形链球菌的水平和血清型。在进行基线采样之后，清洁牙齿，并用抗链霉素的变形链球菌菌株Ingbritt（c型）和OMZ65（g型）接种受试者。测定菌斑和唾液中的植入水平和定植持续时间，并在唾液和血清中监测与这些菌株反应的抗体。去除植入的细菌后，通过每天摄入含有25 mg福尔马林杀死的冷冻干燥的OMZ65细胞的肠溶胶囊来免疫受试者3天，并重复接种。像以前一样监测抗体和植入的水平以及定植的持续时间。在细菌不再被检测到一个月后，重复免疫和接种周期，除了受试者被免疫7天。八名受试者中的五名成功被Ingbritt和OMZ65菌株定殖。其余三个没有被任何一个菌株定殖。 OMZ65菌株的植入水平高于Ingbritt菌株。口服免疫在唾液或血清中未检测到对整个细菌细胞的抗体反应。但是，在第一次和第二次免疫后，OMZ65和Ingbritt的感染峰值水平和定殖持续时间均明显降低。

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