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首页> 外文期刊>Infection and immunity >Age-associated increase in the expression of T-cell antigen receptor gamma-chain gene in conventional and germfree mice.
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Age-associated increase in the expression of T-cell antigen receptor gamma-chain gene in conventional and germfree mice.

机译：在传统和无菌小鼠中，T细胞抗原受体γ链基因的表达与年龄相关。

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摘要

To determine whether environmental antigens such as intestinal microflora contribute to expansion of the T-cell repertoire, age-related changes in the expression level of T-cell antigen receptor genes encoding gamma, beta, and alpha chains were compared in the lymphoid tissues of conventional versus germfree mice. Irrespective of the conditions of maintenance, an age-associated increase in the expression of the gamma-chain gene was evident in the thymus and spleen. Both conventional and germfree old mice (age, 40 weeks) had a relatively high proportion of Thy1+ L3T4- Lyt2- cells but a reduced level of Thy1+ L3T4- Lyt2+ cells in the thymus compared with their counterparts (age 8 weeks). The thymic dysfunction but not the stimulation by intestinal microflora may contribute to this age-related increase in gamma-gene transcripts in these tissues. On the other hand, an age-associated increase in the expression of gamma RNA was not evident in the mesenteric lymph nodes of germfree mice, although a remarkable increase in the gamma-chain gene messages was detected in the lymph nodes of the aged conventional mice. These results suggest that the expression of gamma RNA in cells of gut-associated lymphoid tissue is partly influenced by intestinal microflora.
机译：为了确定环境抗原（例如肠道菌群）是否有助于T细胞库的扩增，比较了常规淋巴组织中编码γ，β和α链的T细胞抗原受体基因表达水平的年龄相关变化。与无菌小鼠相比。不论维持的条件如何，在胸腺和脾脏中，γ链基因的表达均与年龄相关。与同龄小鼠（8周龄）相比，传统和无菌老龄小鼠（40周龄）的Thy1 + L3T4-Lyt2-细胞比例都相对较高，但胸腺中Thy1 + L3T4-Lyt2 +细胞的水平却降低了。胸腺功能障碍而不是肠道菌群的刺激可能是这些组织中γ基因转录本与年龄相关的增加的原因。另一方面，在无菌小鼠的肠系膜淋巴结中，与年龄相关的γRNA表达的增加并不明显，尽管在老年传统小鼠的淋巴结中发现了γ链基因信息的显着增加。 。这些结果表明肠道相关淋巴组织细胞中γRNA的表达部分受到肠道菌群的影响。

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