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首页> 外文期刊>Infection and immunity >Cholera Toxin Induces Migration of Dendritic Cells from the Subepithelial Dome Region to T- and B-Cell Areas of Peyer's Patches
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Cholera Toxin Induces Migration of Dendritic Cells from the Subepithelial Dome Region to T- and B-Cell Areas of Peyer's Patches

机译：霍乱毒素诱导树突状细胞从上皮下圆顶区迁移到淋巴集结的T细胞和B细胞区域

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Intestinal M cells deliver macromolecules, particles, and pathogens into the subepithelial dome (SED) region of Peyer's patch mucosa, an area rich in dendritic cells (DCs). We tested whether uptake of the mucosal adjuvant cholera toxin (CT) or live Salmonella bacteria can induce DC migration within Peyer's patches. Virus-sized, fluorescent polystyrene microparticles were efficiently transported by M cells and ingested by CD11c+, CD11b?, and CD8a? DCs in the SED region. DCs loaded with microparticles remained in the SED for up to 14 days. CT (but not the CT B subunit) and live attenuated Salmonella enterica serovar Typhimurium bacteria induced migration of the microparticle-loaded DCs from the SED region into underlying B-cell follicles and adjacent parafollicular T-cell zones. Our data provide the first demonstration that DCs move in response to enterotoxin adjuvants and live bacteria that enter the mucosa via M cells.
机译：肠道M细胞将大分子，颗粒和病原体输送到Peyer's修补黏膜的上皮下圆顶（SED）区域，该区域富含树突状细胞（DC）。我们测试了摄取黏膜佐剂霍乱毒素（CT）或活的沙门氏菌细菌是否可以诱导Peyer斑块内的DC迁移。病毒大小的荧光聚苯乙烯微粒可被M细胞有效转运，并被SED中的CD11c + ，CD11b ？和CD8a ？ DC摄取。地区。装有微粒的DC保留在SED中长达14天。 CT（但不是CT B亚基）和减毒的活型鼠伤寒沙门氏菌引起了载有微粒的DC从SED区域迁移到下面的B细胞滤泡和邻近的滤泡旁T细胞区。我们的数据提供了第一个证明，DC对肠毒素佐剂和通过M细胞进入粘膜的活细菌有反应。

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