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首页> 外文期刊>Infection and immunity >Comparative Genomics Identifies the Genetic Islands That Distinguish Neisseria meningitidis, the Agent of Cerebrospinal Meningitis, from Other Neisseria Species
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Comparative Genomics Identifies the Genetic Islands That Distinguish Neisseria meningitidis, the Agent of Cerebrospinal Meningitis, from Other Neisseria Species

机译：比较基因组学鉴定出与其他奈瑟菌属物种区别开来的脑膜炎奈瑟菌脑膜炎奈瑟菌的遗传岛

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摘要

Neisseria meningitidis colonizes the nasopharynx and, unlike commensal Neisseria species, is capable of entering the bloodstream, crossing the blood-brain barrier, and invading the meninges. The other pathogenic Neisseria species, Neisseria gonorrhoeae, generally causes an infection which is localized to the genitourinary tract. In order to investigate the genetic basis of this difference in disease profiles, we used a strategy of genomic comparison. We used DNA arrays to compare the genome of N. meningitidis with those of N. gonorrhoeae and Neisseria lactamica, a commensal of the nasopharynx. We thus identified sequences conserved among a representative set of virulent strains which are either specific to N. meningitidis or shared with N. gonorrhoeae but absent from N. lactamica. Though these bacteria express dramatically different pathogenicities, these meningococcal sequences were limited and, in contrast to what has been found in other pathogenic bacterial species, they are not organized in large chromosomal islands.
机译：脑膜炎奈瑟氏球菌定居于鼻咽，与常见的奈瑟氏菌物种不同，它能够进入血流，穿越血脑屏障并侵入脑膜。其他 Neisseria 病原体淋病奈瑟氏球菌通常会导致感染，这种感染局限于泌尿生殖道。为了调查这种疾病谱差异的遗传基础，我们使用了基因组比较策略。我们使用DNA阵列比较了 N的基因组。脑膜炎和 N。淋球菌和乳酸奈瑟氏菌，是鼻咽的标志。因此，我们鉴定了代表性的毒株中保守的序列，这些毒株要么对Nem特异。脑膜炎或与 N共享。淋病科，但 N除外。内酰胺类。尽管这些细菌表现出截然不同的致病性，但这些脑膜炎球菌序列受到限制，并且与其他致病细菌物种发现的相反，它们在大型染色体岛中没有组织。

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