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首页> 外文期刊>Infection and immunity >The Siderophore Receptor IroN of Extraintestinal Pathogenic Escherichia coli Is a Potential Vaccine Candidate
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The Siderophore Receptor IroN of Extraintestinal Pathogenic Escherichia coli Is a Potential Vaccine Candidate

机译：肠外致病性大肠杆菌的铁载体受体IroN是潜在的疫苗候选者

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摘要

It would be medically and economically desirable to prevent the millions of annual extraintestinal infections and the thousands of associated deaths due to Escherichia coli. Outer membrane proteins are potential vaccine candidates for the prevention of these infections. This study tested the hypotheses that the siderophore receptor IroN is antigenic and that an IroN-specific antibody response confers protection in vivo. Subcutaneous immunization with denatured IroN resulted in a significant IroN immunoglobulin G (IgG)-specific response in serum (P < 0.0001) but not a systemic or mucosal IroN-specific IgA response. In a mouse model of ascending urinary tract infection, subcutaneous immunization with denatured IroN conferred significant protection against renal (P = 0.0135 and 0.0095 in two independent experiments), but not bladder, infection. These data, together with the previously demonstrated role of IroN in virulence, its expression in human biologic fluids, and its prevalence among extraintestinal pathogenic E. coli strains, support further studies on the role of IroN as a vaccine candidate.
机译：预防每年因大肠杆菌引起的数百万例肠外感染和数以千计的相关死亡，在医学和经济上都是合乎需要的。外膜蛋白是预防这些感染的潜在候选疫苗。这项研究检验了铁载体受体IroN具有抗原性且IroN特异性抗体应答可在体内提供保护的假设。变性的IroN进行皮下免疫会导致血清中显着的IroN免疫球蛋白G（IgG）特异性应答（ P <0.0001），而不是全身或粘膜IroN特异性IgA应答。在升尿路感染的小鼠模型中，用变性的IroN进行皮下免疫可显着保护肾脏（在两个独立的实验中， P = 0.0135和0.0095），而不是膀胱感染。这些数据以及先前证明的IroN在毒力中的作用，其在人类生物体液中的表达及其在肠外致病性 E中的流行。大肠杆菌菌株支持IroN作为候选疫苗的作用的进一步研究。

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