The Salmochelin Siderophore Receptor IroN Contributes to Invasion of Urothelial Cells by Extraintestinal Pathogenic Escherichia coli In Vitro

Friederike Feldmann; Liisa Johanna Sorsa; Kirsten Hildinger; S?ren Schubert

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The Salmochelin Siderophore Receptor IroN Contributes to Invasion of Urothelial Cells by Extraintestinal Pathogenic Escherichia coli In Vitro

机译：Salmochelin铁载体受体IroN有助于肠外致病性大肠杆菌对尿道上皮细胞的侵袭。

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Extraintestinal pathogenic Escherichia coli (ExPEC) strains possess several siderophore-dependent iron uptake systems. In this study we demonstrated that the salmochelin siderophore receptor IroN is involved in the invasion of urothelial cells by ExPEC in vitro. Thus, IroN may play a dual role in the establishment of urinary tract infections, displaying an iron uptake receptor as well as an internalization factor.

机译：肠外致病性大肠埃希氏菌（ExPEC）菌株具有多种铁载体依赖的铁吸收系统。在这项研究中，我们证明了Salmochelin铁载体受体IroN参与了ExPEC在体外对尿路上皮细胞的侵袭。因此，IroN可能在尿路感染的建立中起双重作用，表现出铁摄取受体以及内在化因子。

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《Infection and immunity》 |2007年第6期|共5页
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Friederike Feldmann; Liisa Johanna Sorsa; Kirsten Hildinger; S?ren Schubert;
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中图分类医学免疫学;
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1. The salmochelin receptor IroN itself, but not salmochelin-mediated iron uptake promotes biofilm formation in extraintestinal pathogenic Escherichia coli (ExPEC) [J] . Magistro Giuseppe, Hoffmann Christiane, Schubert Soeren International journal of medical microbiology: IJMM . 2015,第4a5期

机译：salmochelin受体IroN本身，但不由salmochelin介导的铁吸收促进肠外病原性大肠杆菌（ExPEC）中的生物膜形成。
2. Roles of iron acquisition systems in virulence of extraintestinal pathogenic Escherichia coli: salmochelin and aerobactin contribute more to virulence than heme in a chicken infection model [J] . Qingqing Gao, Xiaobo Wang, Huiqing Xu, BMC Microbiology . 2012,第1期

机译：铁捕获系统在肠外致病性大肠杆菌毒力中的作用：在鸡感染模型中，沙门麦角菌素和航空杆菌素对毒力的作用比血红素的作用大
3. The Siderophore Receptor IroN of Extraintestinal Pathogenic Escherichia coli Is a Potential Vaccine Candidate [J] . Thomas A. Russo, Catherine D. McFadden, Ulrike B. Carlino-MacDonald, Infection and immunity . 2003,第12期

机译：肠外致病性大肠杆菌的铁载体受体IroN是潜在的疫苗候选者
4. Both Flagella and F4 Fimbriae Contribute F4ac+Enterotoxigenic Escherichia coli Adhering to IPEC-J2 Cells in vitro [C] . Zhou Mingxu, Duan Qiangde, Zhu Xiaofang, 16th International congress on animal hygiene : animal hygiene, health and welfare as corner stones of sustainable animal production . 2013

机译：鞭毛和F4菌毛均有助于F4ac +产肠毒素的大肠杆菌在体外粘附IPEC-J2细胞
5. Iron acquisition by uropathogenic Escherichia coli: ChuA and Hma heme receptors as virulence determinants and vaccine targets. [D] . Hagan, Erin Courtney. 2009

机译：尿致病性大肠杆菌获得铁：ChuA和Hma血红素受体作为毒力决定因素和疫苗靶标。
6. The Salmochelin Siderophore Receptor IroN Contributes to Invasion of Urothelial Cells by Extraintestinal Pathogenic Escherichia coli In Vitro [O] . Friederike Feldmann, Liisa Johanna Sorsa, Kirsten Hildinger, 2007

机译：Salmochelin铁载体受体IroN有助于肠外致病性大肠杆菌对尿道上皮细胞的侵袭。
7. The Salmochelin Siderophore Receptor IroN Contributes to Invasion of Urothelial Cells by Extraintestinal Pathogenic Escherichia coli In Vitro▿ [O] . Feldmann, Friederike, Sorsa, Liisa Johanna, Hildinger, Kirsten, 2007

机译：Salmochelin铁载体受体IroN有助于肠道外致病性大肠杆菌体外侵袭尿道上皮细胞。

The Salmochelin Siderophore Receptor IroN Contributes to Invasion of Urothelial Cells by Extraintestinal Pathogenic Escherichia coli In Vitro

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