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Dendritic Cell Populations in Leishmania major-Infected Skin and Draining Lymph Nodes

机译：利什曼原虫主要感染的皮肤和引流淋巴结中的树突状细胞群

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Using a metacyclic promastigote ear infection model of cutaneous leishmaniasis, we examined the phenotype, parasite load, and cytokine production of dendritic cells in the skin and draining lymph nodes of resistant C57BL/6J and susceptible BALB/c mice. Five dendritic cell populations were isolated from the skin and lymph nodes, and the main difference between the groups of mice was an increased number of plasmacytoid dendritic cells in the lymph nodes of the susceptible mice. Although similar cell types were present in the skin emigrants of both strains, there was a 10-fold larger number of cells in BALB/c mouse skin early in infection than in C57BL/6J mouse skin. None of the dendritic cells in the lymph nodes harbored parasites until 3 weeks after infection, with the Langerhans cells having the largest load and the plasmacytoid dendritic cells having the smallest load but the longest lasting infection. Although parasites could be detected in the lymph nodes a few hours after infection, none of the skin emigrants harbored parasites, indicating that they are not the vehicle that ferries the parasites from the skin to the lymph nodes. The presence of larger numbers of plasmacytoid cells in infected BALB/c mice, the more protracted infection of these cells, and their production of alpha interferon point to a complex and important role for the plasmacytoid cells in leishmaniasis.
机译：我们使用皮肤利什曼病的亚环前鞭毛体耳部感染模型，研究了耐药性C57BL / 6J和易感BALB / c小鼠的皮肤和引流淋巴结中树突状细胞的表型，寄生虫负荷和细胞因子的产生。从皮肤和淋巴结中分离出五个树突细胞群，小鼠组之间的主要区别是易感小鼠的淋巴结中浆细胞样树突细胞数量增加。尽管两种菌株的皮肤迁移物中都存在相似的细胞类型，但感染早期，BALB / c小鼠皮肤中的细胞数量比C57BL / 6J小鼠皮肤中的细胞数量大10倍。直到感染后3周，淋巴结中的树突状细胞都没有寄生虫，其中朗格汉斯细胞具有最大的负荷，而浆细胞样树突状细胞具有最小的负荷但持续时间最长。尽管感染后数小时可在淋巴结中检测到寄生虫，但没有皮肤移徙者携带寄生虫，这表明它们不是将寄生虫从皮肤运送到淋巴结的媒介。在感染的BALB / c小鼠中存在大量浆细胞样细胞，这些细胞感染时间越长，它们产生的α干扰素表明浆细胞样细胞在利什曼病中具有复杂而重要的作用。

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