• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Purification and immunological characterization of a GroEL-like protein from Bordetella pertussis.
【24h】

Purification and immunological characterization of a GroEL-like protein from Bordetella pertussis.

机译：百日咳博德特氏菌GroEL样蛋白的纯化和免疫学表征。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A GroEL-like protein from Bordetella pertussis was purified. This protein was found to have the tetradecameric subunit structure typical of the GroEL family of proteins and to contain epitopes similar to those of other members of this family, including a human GroEL-like protein. Active immunization of neonatal mice with the B. pertussis GroEL-like protein provided little protection against an aerosol challenge with B. pertussis. Antibodies to this protein were elicited in mice by a standard diphtheria-tetanus-pertussis (DTP) vaccine but not by an experimental acellular pertussis vaccine. Since the Bordetella GroEL-like protein was found to contain epitopes similar to those on the mammalian analog, the potential exists that vaccination with standard DTP vaccines may induce antibodies which react with the mammalian GroEL analog.
机译：纯化了来自百日咳博德特氏菌的GroEL-样蛋白。发现该蛋白质具有典型的GroEL蛋白质家族的十四聚体亚基结构，并包含与该家族其他成员类似的表位，包括人类GroEL样蛋白质。用百日咳博德特氏菌主动免疫新生小鼠GroEL样蛋白对百日咳博德特氏菌的气溶胶攻击几乎没有保护作用。通过标准白喉-破伤风-百日咳（DTP）疫苗在小鼠中引发了针对该蛋白的抗体，但实验性脱细胞百日咳疫苗却没有。由于发现博德特氏菌GroEL样蛋白含有与哺乳动物类似物相似的表位，因此存在潜在的可能性，即用标准DTP疫苗接种可诱导与哺乳动物GroEL类似物反应的抗体。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号