The glycerolipid receptor for Helicobacter pylori (and exoenzyme S) is phosphatidylethanolamine.

C A Lingwood; M Huesca; A Kuksis

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The glycerolipid receptor for Helicobacter pylori (and exoenzyme S) is phosphatidylethanolamine.

机译：幽门螺杆菌（和外切酶S）的甘油脂受体是磷脂酰乙醇胺。

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We have previously shown that Helicobacter pylori specifically binds to a glycerolipid species preferentially found in the antrum of the human stomach. We now show by high-pressure liquid chromatographic analysis that this species is a form of phosphatidylethanolamine and that H. pylori specifically binds to bona fide phosphatidylethanolamine as detected by a thin-layer chromatogram overlay procedure. Considerable variation in the binding of H. pylori to phosphatidylethanolamine from different sources was observed, however, suggesting the importance of the nature of the long-chain hydrophobic moiety. A similar binding specificity was shown by exoenzyme S from Pseudomonas aeruginosa, consistent with our hypothesis that that an exoenzyme S-like adhesin is responsible for the binding of H. pylori to its lipid receptors.

机译：先前我们已经证明幽门螺杆菌特异性结合优先在人胃窦中发现的甘油脂类。现在我们通过高压液相色谱分析表明，该物质是磷脂酰乙醇胺的一种形式，幽门螺杆菌特异性结合至真正的磷脂酰乙醇胺，如薄层色谱图叠加程序所检测。然而，观察到幽门螺杆菌与来自不同来源的磷脂酰乙醇胺的结合有相当大的变化，表明长链疏水部分的性质的重要性。铜绿假单胞菌的外切酶S显示出相似的结合特异性，这与我们的假设一致，即外切酶S样粘附素负责幽门螺杆菌与其脂质受体的结合。

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《Infection and immunity》 |1992年第6期|共5页
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C A Lingwood; M Huesca; A Kuksis;
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中图分类医学免疫学;
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1. Intact Gram-Negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus Bacteria Activate Innate Immunity via Toll-Like Receptor 2 but Not Toll-Like Receptor 4 [J] . Leisa Mandell, Anthony P. Moran, Andrew Cocchiarella, Infection and immunity . 2004,第11期

机译：完整的革兰氏阴性幽门螺杆菌，猫幽门螺杆菌和肝杆菌幽门螺杆菌可通过收费受体2激活先天免疫，但不会通过收费受体4激活先天免疫。
2. The influence of the Chuyou Yuyang granule on the Toll‐like receptor/nuclear factor‐κB signal pathway in Helicobacter pylori Helicobacter pylori ‐positive peptic ulcer patients [J] . Yang Fang, Ge Guiping, Shen Wen, Journal of cellular biochemistry. . 2019,第8期

机译：中友Yuyang颗粒对幽门螺杆菌幽门螺杆菌幽门螺杆菌幽门螺杆菌幽门螺杆菌幽门螺杆菌致病术/核因子-κB信号途径的影响
3. The lipoprotein HP1454HP1454 of Helicobacter pyloriHelicobacter pylori regulates TT ‐cell response by shaping TT ‐cell receptor signalling [J] . Capitani Nagaja, Codolo Gaia, Vallese Francesca, Cellular microbiology . 2019,第5期

机译：幽门螺杆菌的脂蛋白 hp1454 hp1454通过成型 t -ceCTOR调节 T T-CL响应来调节 T T-CL响应信令
4. Immobilization of specific receptors for Helicobacter pylori using model surfaces [C] . P. Parreira, A. MagalhSes, C. A. Reis, European conference on biomaterials;ESB 2010 . 2010

机译：使用模型表面固定幽门螺杆菌的特定受体
5. Discovery of CZB, a novel zinc-binding domain in bacterial chemoreceptors & the genome sequence of Helicobacter pylori strain SS1. [D] . Draper, Jenny Lyn. 2010

机译：在细菌化学感受器和幽门螺杆菌SS1的基因组序列中发现了新型的锌结合域CZB。
6. The glycerolipid receptor for Helicobacter pylori (and exoenzyme S) is phosphatidylethanolamine. [O] . C A Lingwood, M Huesca, A Kuksis 1992

机译：幽门螺杆菌（和外酶S）的甘油脂受体是磷脂酰乙醇胺。
7. Intact Gram-Negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus Bacteria Activate Innate Immunity via Toll-Like Receptor 2 but Not Toll-Like Receptor 4 [O] . Mandell, Leisa, Moran, Anthony P., Cocchiarella, Andrew, 2004

机译：完整的革兰氏阴性幽门螺杆菌，猫幽门螺杆菌和肝杆菌幽门螺杆菌可通过收费受体2激活先天免疫，但不会通过收费受体4激活先天免疫。

The glycerolipid receptor for Helicobacter pylori (and exoenzyme S) is phosphatidylethanolamine.

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